9.B.227.  The Uncharacterized 9 or 10 TMS YndJ (YndJ) Family 

Nothing is known about the functions of these proteins, but many are present in the NCBI protein database as it is a large family of conserved membrane proteins. The YndJ family includes numberous proteins of about the same size and topology.  One publication described work on a homologue of this family, but the function was not revealed (Joshi and McSpadden Gardener 2006).


 

References:

Joshi, R. and B.B. McSpadden Gardener. (2006). Identification and Characterization of Novel Genetic Markers Associated with Biological Control Activities in Bacillus subtilis. Phytopathology 96: 145-154.
Examples:

TC#NameOrganismal TypeExample
9.B.227.1.1

YndJ homologue with 10 TMSs (N-terminal, in a 2 + 2 + 2 + 2 + 2 TMS arrangement) and a hydrophilic C-terminus of 616 aas.  TPR repeat-containing protein.

Proteobacteria

TndJ of Haniangium ochraceum

 
9.B.227.1.2

Uncharacterized protein of 278 aas and 9 TMSs.  This protein shows 42% identity with the N-terminal 300 residues of 1.B.77.1.10, a two domain protein with a C-terminal domain similar to members of the Oep23 family.

Actinobacteria

UP of Beutenbergia cavernae

 
9.B.227.1.3

Uncharacterized protein of 324 aas and 10 TMSs

Euryarchaota

UP of Haloarcula marismortui

 
9.B.227.1.4

Uncharacterized protein of 423 aas and 11 TMSs

Actinobacteria

UP of Streptomyces venezuelae

 
9.B.227.1.5

Uncharacterized protein, YndJ, of 546 aas (Joshi and McSpadden Gardener 2006).

Firmicutes

YndJ of Bacillus subtilis

 
9.B.227.1.6

Uncharacterized protein, YndJ, of 325 aas and 9 putative TMSs.

Proteobacteria

YndJ homologue of Plesiocystis pacifica

 
Examples:

TC#NameOrganismal TypeExample
9.B.227.2.1

Uncharacterized protein of 330 aas and 9 TMSs.

UP of Verrucosispora maris

 
9.B.227.2.2

Uncharacterized protein of 305 aas and 8 TMSs

UP of Nostoc azollae (Anabaena azollae

 
9.B.227.2.3

Uncharacterized protein of 311 aas and 7 TMSs.

UP of Coraliomargarita akajimensis

 

 
9.B.227.2.4

Phosphatidylglycerol lysyltransferase, MprF of 314 aas and 8 TMSs in a 2 + 2 + 4 TMS arrangement.  Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.

PG lysyltransferase of Ruminococcus callidus

 
9.B.227.2.5

Uncharacterized protein of 355 aas and 7 TMSs.

UP of Gimesia maris

 
9.B.227.2.6

Uncharacterized protein of 438 aas and 11 or 12 TMSs.

UP of Flavobacterium branchiophilum