9.b.346. The Uncharacterized Archaeal 4 or 6 TMS Protein (UA4,6P) Family The UA4,6P family consists of proteins largely from Lokiarchaeota. These proteins can have either 4 or 6 TMSs. There are 3 distantly related subfamilies, subfamilies 1 - 3, and especially subfamily 2 appears to be related to TC families 9.B.183, 9.B.225, and 9.B.142, all of which are glycosyl transferases including the DUF2029 domain-containing proteins, functionally characterized members of which have been shown to be glycosyl transferases. These enzymes are larger than the proteins included in TC family 9.B.346 with 8 - 10 TMSs. Protein 9.B.346.2.2 is annotated as a DUF2029 protein in the NCBI protein database.
This family belongs to the Glycosyl/Acyl Transferase (GAT) Superfamily.
Examples:
TC#	Name	Organismal Type	Example
9.B.346.1.1	UP of 177 aas and 4 TMSs		UP of Candidatus Lokiarchaeon archaeon CR_4

9.B.346.1.2	Uncharacterized protein of 224 aas and 6 TMSs		UP of Candidatus Lokiarchaeota archaeon

9.B.346.1.3	Uncharacterized protein of 236 aas and 6 TMSs		UP of Candidatus Lokiarchaeota archaeon (sediment metagenome)

9.B.346.1.4	Uncharacterized protein of 183 aas and 4 TMSs in a 1 + 3 TMS arrangement		UP of Candidatus Lokiarchaeota archaeon (marine sediment metagenome)

9.B.346.1.5	Uncharacterized protein of 179 aas and 4 TMSs in a 1 + 3 TMS arrangement		UP of Candidatus Lokiarchaeota archaeon (marine sediment metagenome)

9.B.346.1.6	Uncharacterized protein of 194 aas and 4 TMSs in a 1 + 2 + 1 TMS arrangement.		UP of an anaerobic archaeon MK-D1

Examples:
TC#	Name	Organismal Type	Example
9.B.346.2.1	Uncharacterized protein of 360 aas and 8 or 9 TMSs. This protein is probably homologous to DUF2029 domain-containing proteins and is therefore likely to be a glycosyl transferase. The integral membrane enzymes of TC families 9.B.142, 9.B.225 and 9.B.346, the former two being glycosyl transferases, are likely to be homologous.		UP of Lokiarchaeum sp. GC14_75

9.B.346.2.2	DUF2029 domain protein of 306 aas and 6 TMSs. Shows appreciable sequence similarity with TC# 9.B.142.17.9 and is likely to be homologous with it.		DUF2029 domain-containing protein of Candidatus Lokiarchaeota archaeon

Examples:
TC#	Name	Organismal Type	Example
9.B.346.3.1	UP of 140 aas and 4 TMSs		UP of Lokiarchaeum sp. GC14_75

9.B.346.3.2	Uncharacterized protein of 152 aas and 4 TMSs		UP of Candidatus Lokiarchaeota archaeon (sediment metagenome)

Examples:
TC#	Name	Organismal Type	Example
9.B.346.4.1	Uncharacterized protein of 217 aas and 6 TMSs in a 2 + 4 TMS arrangement.		UP of Candidatus Prometheoarchaeum syntrophicum

9.B.346.4.2	Uncharacterized protein of 191 aas and 6 TMSs		UP of Chloroflexi bacterium (marine sediment metagenome)

Examples:
TC#	Name	Organismal Type	Example
9.B.346.5.1	Uncharacterized protein of 235 aas and 6 TMSs in a 2 + 4 TMS arrangement.		UP of Acidobacteria bacterium (sediment metagenome)