9.B.57 The Conidiation and Conidial Germination Protein (CCGP) Family 

The MTP1 gene, encoding a type III integral transmembrane protein, was isolated from the rice blast fungus Magnaporthe oryzae. The Mtp1 protein is 520 amino acids long and is probably orthologous to the Ytp1 protein of Saccharomyces cerevisiae with 46% sequence similarity. Prediction programs and MTP1-GFP (green fluorescent protein) fusion expression results indicated that Mtp1 is a protein located at several membranes exposed to the cytoplasm. The MTP1 gene was primarily expressed at the hyphal and conidial stages and is necessary for conidiation and conidial germination, but is not required for pathogenicity. The Δmtp1 mutant grew more efficiently than the wild type strain on non-fermentable carbon sources, implying that MTP1 has a role in respiratory growth and carbon source use (Lu et al. 2008).


This family belongs to the Major Facilitator (MFS) Superfamily.
 

References:

Lu, Q., J.P. Lu, X.D. Li, X.H. Liu, H. Min, and F.C. Lin. (2008). Magnaporthe oryzae MTP1 gene encodes a type III transmembrane protein involved in conidiation and conidial germination. J Zhejiang Univ Sci B 9: 511-519.
West, R.W., Jr, M.D. Crivellone, J. Ma, and S. Thomas. (1996). Sequence of the Saccharomyces cerevisiae YTP1 gene encoding a deduced novel type-III integral membrane protein with domains of sequence similarity to mitochondrial electron-transport enzymes. Gene 169: 119-124.
Examples:

TC#NameOrganismal TypeExample
9.B.57.1.1

The Mtp1 protein, essential for conidiation and conidial germination, of 520 aas and 12 TMSs (Lu et al. 2008). Has an N-terminal Cytb561 domain and a Ytp1 C-terminal domain.

Mtp1 of Magnaporthe oryzae (Rice blast fungus) (Pyricularia oryzae)

 
9.B.57.1.2

The Ytp1 protein of 459 aas and 12 TMSs (West et al. 1996).

Ytp1 of Saccharomyces cerevisiae

 
9.B.57.1.3

Uncharacterized protein of 602 aas and 12 TMSs.

UP of Thielavia terrestris (Acremonium alabamense)

 
9.B.57.1.4

Uncharacterized protein of 686 aas and 11 TMSs

UP of Absidia glauca

 
9.B.57.1.5

Uncharacterized protein of 981 aas and 12 TMSs

UP of Tilletia caries

 
Examples:

TC#NameOrganismal TypeExample