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2.A.47.1.9
Na+-coupled citrate transporter (NaCT) (Km=20 μM) (also may transport dicarboxylates and other tricarboxylates with lower affinity) (Inoue et al., 2002b; Bergeron et al. 2013). Na+:citrate = 3-4:1 (Wada et al., 2006).Targeting longevity gene SLC13A5 provides a novel approach to preventing age-related bone fragility and osteoporosis (Zahn et al. 2023).  Homozygous variants of SLC13A5 expand the functional heterogeneity of a homogeneous syndrome of early infantile epileptic encephalopathy (Bergeron et al. 2013). Na+:citrate = 3-4:1 (Wada et al., 2006).Targeting longevity gene SLC13A5 provides a novel approach to preventing age-related bone fragility and osteoporosis (Zahn et al. 2023).  Homozygous variants of SLC13A5 expand the functional heterogeneity of a homogeneous syndrome of early infantile epileptic encephalopathy (Alsemari et al. 2024).

Accession Number:Q86YT5
Protein Name:NaCT
Length:568
Molecular Weight:63062.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate sodium(1+), dicarboxylic acid dianion, citrate salt, tricarboxylic acid trianion

Cross database links:

RefSeq: NP_808218.1   
Entrez Gene ID: 284111   
Pfam: PF00939   
OMIM: 608305  gene
KEGG: hsa:284111   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015137 F:citrate transmembrane transporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport
GO:0016323 C:basolateral plasma membrane
GO:0005626 C:insoluble fraction
GO:0005886 C:plasma membrane
GO:0017153 F:sodium:dicarboxylate symporter activity
GO:0015141 F:succinate transmembrane transporter activity

References (9)

[1] “Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function.”  Inoue K.et.al.   12445824
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218
[5] “Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function.”  Inoue K.et.al.   12445824
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.”  Zody M.C.et.al.   16625196
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MASALSYVSK FKSFVILFVT PLLLLPLVIL MPAKFVRCAY VIILMAIYWC TEVIPLAVTS 
61:	LMPVLLFPLF QILDSRQVCV QYMKDTNMLF LGGLIVAVAV ERWNLHKRIA LRTLLWVGAK 
121:	PARLMLGFMG VTALLSMWIS NTATTAMMVP IVEAILQQME ATSAATEAGL ELVDKGKAKE 
181:	LPGSQVIFEG PTLGQQEDQE RKRLCKAMTL CICYAASIGG TATLTGTGPN VVLLGQMNEL 
241:	FPDSKDLVNF ASWFAFAFPN MLVMLLFAWL WLQFVYMRFN FKKSWGCGLE SKKNEKAALK 
301:	VLQEEYRKLG PLSFAEINVL ICFFLLVILW FSRDPGFMPG WLTVAWVEGE TKYVSDATVA 
361:	IFVATLLFIV PSQKPKFNFR SQTEEERKTP FYPPPLLDWK VTQEKVPWGI VLLLGGGFAL 
421:	AKGSEASGLS VWMGKQMEPL HAVPPAAITL ILSLLVAVFT ECTSNVATTT LFLPIFASMS 
481:	RSIGLNPLYI MLPCTLSASF AFMLPVATPP NAIVFTYGHL KVADMVKTGV IMNIIGVFCV 
541:	FLAVNTWGRA IFDLDHFPDW ANVTHIET