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2.A.60.1.4
Organic anion transporter, OatK1 (SLC21A4) (substrates: bile salts, hormones and their conjugates, eicosanoids, toxins, drugs, methotrexate, zidovudine)

Accession Number:P70502
Protein Name:OATK aka OATK1 aka Slc21a4
Length:670
Molecular Weight:73817.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate bile salts, Hormones, Eicosanoids, Toxins, drugs, methotrexate, Zidovudine

Cross database links:

Genevestigator: P70502
eggNOG: maNOG12561
RefSeq: NP_110464.1   
Entrez Gene ID: 80899   
Pfam: PF07648    PF03137   
KEGG: rno:80899   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015350 F:methotrexate transporter activity
GO:0008514 F:organic anion transmembrane transporter act...
GO:0015893 P:drug transport
GO:0015711 P:organic anion transport

References (3)

[1] “Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney.”  Saito H.et.al.   8702823
[2] “Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney.”  Masuda S.et.al.   10101033
[3] “Cloning and tissue-specific expression of spliced variants of the rat organic anion transporter (rOAT-K).”  Wolff M.W.et.al.   12180133

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGDLEKGAAT HGAGCFAKIK VFLMALTCAY VSKSLSGTFM SSMLTQIERQ FGIPTAIVGF 
61:	INGSFEIGNL LLIIFVSYFG MKLHRPIVIG VGCAVMGLGC FIISLPHFLM GRYEYETTIL 
121:	PTSNLSSNSF LCMENQTQTL NPAQDPAECV KEVKSLMWIY VLVGNIIRGI GETPIMPLGV 
181:	SYIENFAKSE NSPLYIGILE TGKMIGPIFG LLLGSFCASI YVDTGSVNTD DLTITPTDIR 
241:	WVGAWWIGFL VCAGVNILIS IPFFFFPKTL PKEGLQENVD GTENAKEEST EKRPRKKNRG 
301:	ITKDFFPFLK SPVLQPDLHA VHPYKVLQVN AFNIYFSFLP KYLENQYGKS TAEVIFLMGV 
361:	YNLPAICIGY LIAGFMMKKF KITVKTAAFL AFCLSLSEYS FGFCNFLITC DNVPVAGLTN 
421:	SYERDQKPLY LENNVLADCN TRCSCLTKTW DPVCGDNGLA YMSACLAGCE KSVGTGTNMV 
481:	FHNCSCIQSP GNSSAVLGLC NKGPECTNKL QYLLILSGFL SILYSFAAIP GYMVFLRCIK 
541:	SEEKSLGIGI HAFCIRVFAG IPAPIYFGAL IDRTCLHWGT QKCGAPGACR MYDINSFRRI 
601:	YLGMSAALRG SSYLPAFVIV ILTRKFSLPG KINSSEMEIA EMKLTEKESQ CTDVHRNPKF 
661:	KNDGELKTKL