| |
---|---|
Accession Number: | P70502 |
Protein Name: | OATK aka OATK1 aka Slc21a4 |
Length: | 670 |
Molecular Weight: | 73817.00 |
Species: | Rattus norvegicus (Rat) [10116] |
Number of TMSs: | 12 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | methotrexate, icosanoid, hormone, bile acid, drug, toxin, zidovudine |
Cross database links:
RefSeq: | NP_110464.1 |
---|---|
Entrez Gene ID: | 80899 |
Pfam: | PF07648 PF03137 |
KEGG: | rno:80899 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0015350
F:methotrexate transporter activity
GO:0008514
F:organic anion transmembrane transporter act...
GO:0015893
P:drug transport
GO:0015711
P:organic anion transport
| |
References (3)[1] “Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney.” Saito H.et.al. 8702823 |
External Searches:
|
Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
|
1: MGDLEKGAAT HGAGCFAKIK VFLMALTCAY VSKSLSGTFM SSMLTQIERQ FGIPTAIVGF 61: INGSFEIGNL LLIIFVSYFG MKLHRPIVIG VGCAVMGLGC FIISLPHFLM GRYEYETTIL 121: PTSNLSSNSF LCMENQTQTL NPAQDPAECV KEVKSLMWIY VLVGNIIRGI GETPIMPLGV 181: SYIENFAKSE NSPLYIGILE TGKMIGPIFG LLLGSFCASI YVDTGSVNTD DLTITPTDIR 241: WVGAWWIGFL VCAGVNILIS IPFFFFPKTL PKEGLQENVD GTENAKEEST EKRPRKKNRG 301: ITKDFFPFLK SPVLQPDLHA VHPYKVLQVN AFNIYFSFLP KYLENQYGKS TAEVIFLMGV 361: YNLPAICIGY LIAGFMMKKF KITVKTAAFL AFCLSLSEYS FGFCNFLITC DNVPVAGLTN 421: SYERDQKPLY LENNVLADCN TRCSCLTKTW DPVCGDNGLA YMSACLAGCE KSVGTGTNMV 481: FHNCSCIQSP GNSSAVLGLC NKGPECTNKL QYLLILSGFL SILYSFAAIP GYMVFLRCIK 541: SEEKSLGIGI HAFCIRVFAG IPAPIYFGAL IDRTCLHWGT QKCGAPGACR MYDINSFRRI 601: YLGMSAALRG SSYLPAFVIV ILTRKFSLPG KINSSEMEIA EMKLTEKESQ CTDVHRNPKF 661: KNDGELKTKL