2.A.6.3.12
The multidrug efflux porter, HefABC; HefA is an OMF (TC#1.b.17) of 477 aas and 1 N-terminal TMS; HefB is an MFP (TC# 8.A.1) of 234 aas and 1 N-terminal TMS. HefC is the RND pump of 1028 aas and 12 TMSs (Mehrabadi et al. 2011; Liu et al. 2008).
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| Accession Number: | B6JLI8 |
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| Protein Name: | Outer-membrane protein of the HefABC efflux system HefA |
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| Length: | 477 |
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| Molecular Weight: | 54543.00 |
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| Species: | Helicobacter pylori (strain P12) [570508] |
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| Substrate |
drug |
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1: MNTIIRYASL WGLCAALTLA QAPSKTPDEI KQILNNYSHK NLKLIDPPTS SLEATPSFLS
61: SPKETATTIN QEIAKYHEKS DKAALGLYEL LKGATTNLSL QAQELSVKQA MKNHTIAKAM
121: FLPTLNASYN FKNEARDTPE YKHYNTQQLQ AQVTLNVFNG FSNVNNVKEK SATYRSTVAN
181: LEYSRQSVYL QVVQQYYEYF NNLARMIALQ KKLEQIKTDI KRVTKLYDKG LTTIDDLQSL
241: KAQGNLSEYD ILDMQFALEQ NRLTLEYLTN LSVKNLKKTT IDAPNLQLRE RQDLVSLREQ
301: ISALRYQNKQ LNYYPKIDVF DSWLFWIQKP AYATGRFGNF YPGQQNTAGV TATLNIFDDI
361: GLSLQKQSIM LGQLANEKNL AYKKLEQEKD EQLYRKSLDI ARAKIESSKA SLDAANLSFA
421: NIKRKYDANL VDFTTYLRGL TTRFDAEVAY NLALNNYEVQ KANYIFNSGH KIDDYVH