2.A.6.3.12
The multidrug efflux porter, HefABC; HefA is an OMF (TC#1.b.17) of 477 aas and 1 N-terminal TMS; HefB is an MFP (TC# 8.A.1) of 234 aas and 1 N-terminal TMS. HefC is the RND pump of 1028 aas and 12 TMSs (Mehrabadi et al. 2011; Liu et al. 2008).
|
| Accession Number: | B6JLJ0 |
|---|
| Protein Name: | Cytoplasmic pump protein of the HefABC efflux system HefC |
|---|
| Length: | 1028 |
|---|
| Molecular Weight: | 113630.00 |
|---|
| Species: | Helicobacter pylori (strain P12) [570508] |
|---|
| Number of TMSs: | 12 |
|---|
| Substrate |
drug |
|---|
1: MYKTAINRPI TTLMFALAIV FFGVMGFKKL SVALFPKIDL PTVVVTTTYP GASAEIIESK
61: VTDKIEEAVM GIDGIKKVTS TSSKNVSIVV IEFELEKPNE EALNDVVNKI SSVRFDDSNI
121: KKPSINKFDT DSQAIISLFV SSSSVPATTL NDYAKNTIKP MLQKINGVGG VQLNGFRERQ
181: IRIYADPTLM NKYNLTYADL FSTLKAENVE IDGGRIVNSQ RELSILINAN SYSVADVEKI
241: QVGNHVRLGD IAKIEIGLEE DNTFASFKDK PGVILEIQKI AGANEIEIVD RVYEALKHIQ
301: AISPSYEIRP FLDTTSYIRT SIEDVKFDLV LGAILAVLVV FAFLRNGTIT LVSAISIPIS
361: IMGTFALIQW MGFSLNMLTM VALTLAIGII IDDAIVVIEN IHKKLEMGMS KRKASYEGVR
421: EIGFALVAIS AMLLSVFVPI GNMKGIIGRF FQSFGITVAL AIALSYVVVV TIIPMVSSVV
481: VNPRHSRFYV WSEPFFKALE SRYTKLLQWV LNHKLIISIA VVLVFVGSLF VASKLGMDFM
541: LKEDRGRFLV WLKAKPGVSI DYMTQKSKIF QKAIEKHAEV EFTTLQVGYG TTQNPFKAKI
601: FVQLKPLKER KKEGELGQFE LMHALRKELR SLPEAKGLDT INLSEVALIG GGGDSSPFQT
661: FVFSHSQEAV DKSVENLRKF LLESPELKGK VESYHTSTSE SQPQLQLKIL RQNANKYGVS
721: AQTIGSVVSS AFSGTSQASV FKEDGKEYDM IIRVPDDKRV SVEDIKRLQV RNKYDKLMFL
781: DALVEITETK SPSSISRYNR QRSVTVLAEP NRNAGVSLGE ILTQVSKNTK EWLVEGANYR
841: FTGEADNAKE SNGEFLIALA TAFVLIYMIL AALYESILEP FIIMVTMPLS FSGAFFALGL
901: VHQPLSMFSM IGLILLIGMV GKNATLLIDV ANEERKKGLN IQEAILFAGK TRLRPILMTT
961: IAMVCGMLPL ALASGDGAAM KSPIGIAMSG GLMISMVLSL LIVPVFYRLL APIDDKIKRF
1021: YQNQKTLE