3.A.1.135.7
Multidrug exporter, EfrAB. Confers resistance to many structurally unrelated antimicrobial agents, such as
norfloxacin, ciprofloxacin, doxycycline, acriflavine,
4,6-diamidino-2-phenylindole, tetraphenylphosphonium chloride,
daunorubicin, and doxorubicin (Lee et al. 2003). Induced by half minimal inhibitory concentrations (MIC) of gentamicin, streptomycin and chloramphenicol which are also exporter (Lavilla Lerma et al. 2014). In some strains, this system may not be the primary drug exporter (Hürlimann et al. 2016).
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| Accession Number: | E2YHZ7 |
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| Protein Name: | ABC transporter, ATP-binding protein |
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| Length: | 589 |
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| Molecular Weight: | 65835.00 |
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| Species: | Enterococcus faecalis DAPTO 512 [749489] |
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| Number of TMSs: | 7 |
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| Substrate |
ciprofloxacin, norfloxacin, doxorubicin, daunorubicin, doxycycline, 3,6-diamino-10-methylacridinium chloride |
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1: MKHAFSSMKR IGRYIKPYRV TFYLVILFTI LTVAFNAALP YLTGLPTTEI SRNIAAGESI
61: NFDYVIQCLI WILVVGTGYC VAQFLSGFLM TNVVQQSMRD LRRDIEEKIN RLPVSYFDKN
121: QQGNILSRVT NDVDAVSNAM QQSFINIVSA VLGIVMAVVM MFLINPLMAI FSVIMIPLSL
181: IISRTIVKIS QKYFQGMQNS LGDLNGYVQE NMTGFSVLKL YGREKETLEG FKQVNHRLNG
241: FGFKASFISG LMLPLVQMTA YGTYIGVAVL GSYYVVAGVI VVGQLQAFIQ YIWQISQPMG
301: NITQLSAALQ SASASTMRIF EILDEPEEEL NEQDVPLPEP ILGSVEFENV SFSYDPEKPL
361: IRNLNFKVDA GQMVAIVGPT GAGKTTLINL LMRFYDVTEG AIKIDGIDTK KMNRSDVRSV
421: FGMVLQDAWL YKGTIADNIR FGKLDATDYE VVDAAKTANV DHFIRTMPDG YEMEINSEGD
481: NVSLGQKQLL TIARAVISDP KILILDEATS SVDTRLEALI QKAMDRVMEG RTSFVIAHRL
541: STIREADLIL VMKQGEIIEK GTHHELLEQG GFYEKLYNSQ FAEEGDYEE