The FtsX/FtsE ABC transporter (Arends et al., 2009) (FtsX is of the type III topology). FtsEX directly recruits EnvC to the septum via an interaction between EnvC and a periplasmic loop of FtsX. FtsEX variants predicted to be ATPase defective still recruit EnvC to the septum but fail to promote cell separation. Amidase activation via EnvC in the periplasm is regulated by conformational changes in the FtsEX complex mediated by ATP hydrolysis in the cytoplasm. Since FtsE has been reported to interact with FtsZ, amidase activity may be coupled with the contraction of the FtsZ cytoskeletal ring (Yang et al., 2011).
|Protein Name:||Cell division ATP-binding protein FtsE|
|Species:||Escherichia coli (strain K12)  |
|Number of TMSs:||1|
1: MIRFEHVSKA YLGGRQALQG VTFHMQPGEM AFLTGHSGAG KSTLLKLICG IERPSAGKIW
61: FSGHDITRLK NREVPFLRRQ IGMIFQDHHL LMDRTVYDNV AIPLIIAGAS GDDIRRRVSA
121: ALDKVGLLDK AKNFPIQLSG GEQQRVGIAR AVVNKPAVLL ADEPTGNLDD ALSEGILRLF
181: EEFNRVGVTV LMATHDINLI SRRSYRMLTL SDGHLHGGVG HE