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9.A.17.1.1
The Pex3/Pex16/Pex19 peroxisomal protein importer (for insertion of integral membranes from the cytosol to the peroxisomal membrane) (Matsuzono and Fujiki, 2006).  Pex3 promotes formation of peroxisome-peroxisome and peroxisome-lipid droplet contact sites (Amado et al. 2025).  Pex3 is a conserved multifunctional peroxisomal transmembrane protein that is involved in the insertion of peroxisomal membrane proteins, in pexophagy, and in the formation of membrane contact sites. High Pex3 levels in Saccharomyces cerevisiae induce the formation of peroxisome clusters surrounded by lipid droplets, mediated by peroxisome-peroxisome and peroxisome-lipid droplet contact sites (Amado et al. 2025).

Accession Number:P28795
Protein Name:Pex3 aka Peroxin-3
Length:441
Molecular Weight:50676.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Peroxisome membrane1 / Single-pass membrane protein2
Substrate protein polypeptide chain

Cross database links:

DIP: DIP-2477N
RefSeq: NP_010616.1   
Entrez Gene ID: 851929   
Pfam: PF04882   
KEGG: sce:YDR329C   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0005779 C:integral to peroxisomal membrane
GO:0005515 F:protein binding
GO:0032581 P:ER-dependent peroxisome organization
GO:0045033 P:peroxisome inheritance
GO:0045046 P:protein import into peroxisome membrane

References (4)

[1] “PAS3, a Saccharomyces cerevisiae gene encoding a peroxisomal integral membrane protein essential for peroxisome biogenesis.”  Hoehfeld J.et.al.   1894692
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[3] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[4] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAPNQRSRSL LQRHRGKVLI SLTGIAALFT TGSVVVFFVK RWLYKQQLRI TEQHFIKEQI 
61:	KRRFEQTQED SLYTIYELLP VWRMVLNEND LNLDSIVTQL KDQKNQLTRA KSSESRESSP 
121:	LKSKAELWNE LELKSLIKLV TVTYTVSSLI LLTRLQLNIL TRNEYLDSAI KLTMQQENCN 
181:	KLQNRFYNWV TSWWSDPEDK ADDAMVMAAK KSKKEGQEVY INEQAFLSLS WWILNKGWLS 
241:	YNEIITNQIE IEFDGIHPRD TLTLEEFSSR LTNIFRNTNS QIFQQNNNNL TSILLPKDSS 
301:	GQEFLLSQTL DADALTSFHS NTLVFNQLVN ELTQCIESTA TSIVLESLIN ESFHFIMNKV 
361:	GIKTIAKKKP GQEDQQQYQM AVFAMSMKDC CQEMLQTTAG SSHSGSVNEY LATLDSVQPL 
421:	DDLSASVYSN FGVSSSFSFK P