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Accession Number: | P29973 |
Protein Name: | CNGA1 |
Length: | 690 |
Molecular Weight: | 79586.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 6 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | cation, inorganic cation |
Cross database links:
RefSeq: | NP_000078.2 NP_001136036.1 |
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Entrez Gene ID: | 1259 |
Pfam: | PF00027 PF00520 |
OMIM: |
123825 gene 268000 phenotype |
KEGG: | hsa:1259 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0030553
F:cGMP binding
GO:0005216
F:ion channel activity
GO:0006811
P:ion transport
GO:0050896
P:response to stimulus
GO:0055085
P:transmembrane transport
GO:0007601
P:visual perception
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References (7)[1] “Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel.” Pittler S.J.et.al. 1372902 [2] “Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression.” Dhallan R.S.et.al. 1379636 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 [5] “Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells.” Distler M.et.al. 7532814 [6] “Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa.” Dryja T.P.et.al. 7479749 [7] “Autosomal recessive retinitis pigmentosa in a Pakistani family mapped to CNGA1 with identification of a novel mutation.” Zhang Q.et.al. 15570217
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External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MKLSMKNNII NTQQSFVTMP NVIVPDIEKE IRRMENGACS SFSEDDDSAS TSEESENENP 61: HARGSFSYKS LRKGGPSQRE QYLPGAIALF NVNNSSNKDQ EPEEKKKKKK EKKSKSDDKN 121: ENKNDPEKKK KKKDKEKKKK EEKSKDKKEE EKKEVVVIDP SGNTYYNWLF CITLPVMYNW 181: TMVIARACFD ELQSDYLEYW LILDYVSDIV YLIDMFVRTR TGYLEQGLLV KEELKLINKY 241: KSNLQFKLDV LSLIPTDLLY FKLGWNYPEI RLNRLLRFSR MFEFFQRTET RTNYPNIFRI 301: SNLVMYIVII IHWNACVFYS ISKAIGFGND TWVYPDINDP EFGRLARKYV YSLYWSTLTL 361: TTIGETPPPV RDSEYVFVVV DFLIGVLIFA TIVGNIGSMI SNMNAARAEF QARIDAIKQY 421: MHFRNVSKDM EKRVIKWFDY LWTNKKTVDE KEVLKYLPDK LRAEIAINVH LDTLKKVRIF 481: ADCEAGLLVE LVLKLQPQVY SPGDYICKKG DIGREMYIIK EGKLAVVADD GVTQFVVLSD 541: GSYFGEISIL NIKGSKAGNR RTANIKSIGY SDLFCLSKDD LMEALTEYPD AKTMLEEKGK 601: QILMKDGLLD LNIANAGSDP KDLEEKVTRM EGSVDLLQTR FARILAEYES MQQKLKQRLT 661: KVEKFLKPLI DTEFSSIEGP GAESGPIDST