9.A.34.1.1
The nuclear export protein complex, Brr6-Brl1-Apq12 (de Bruyn Kops and Guthrie 2001). Apq12 may be involved
in the regulation of lipid homeostasis in the endoplasmic reticulum,
thereby impacting nuclear pore complex biogenesis and localization, and
nucleocytoplasmic mRNA transport (Lone et al. 2015). Brr6 and the C-terminal 140 aas of Brl1 are homologous. An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae (Kralt et al. 2022).
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| Accession Number: | P38770 |
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| Protein Name: | Nucleus export protein BRL1 |
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| Length: | 471 |
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| Molecular Weight: | 53385.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Nucleus membrane1 / Multi-pass membrane protein2 |
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| Substrate |
messenger RNA |
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1: MESFENLSIR DSFTSGMEHV DEELGGLSDL SISKQGPTLS PQLINRFMPH FPSSPSPLRN
61: TLDFSAAKAD EEEDDRMEID EVDDTSFEEE YNNEPIETHT EATENAVVEE IEATPEERQK
121: QEKNESQDQS VEEVENIVSP HRSTVIKALL SPTDLGVAAA TKVEGVVPLP PSANQDDNES
181: SNNNAEGEDI IRNEEVEDEI KSSLGNHKSS QYANAFDSEI IKRELRSRSK YQPIQVSFNT
241: HNYFYSDKDG IKTYSLTKPN HNKIDEFYDQ NEAFKLPKPW SPNSHPASRA SYALMSYLQL
301: FLNAITTVVI FSFILSFIIA LQKDLKSTWE QRKHELQYES RICQEQYLTN RCNQTPGLPA
361: LGEQCAIWKQ CMDRNNDIFF RARSTLSAKL FGDIINSFID PLNWKTLFVI FCGVITWCFS
421: SNFLLGFVRA KSYYGNGIKT YPLPSSPKSP TSEETHSSMT ASGEDSHLLK Q