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3.A.1.203.6
Peroxisomal long-chain fatty acid/oleic acid importer, PXA1 (Pat2)/PXA2 (Pat1) (Lamping et al., 2010; van Roermund et al., 2011).  PXA1 and PXA2 are two half-ABC transport subunits that can form a heterodimer. They are of 870 and 853 aas, respectively, both probably with 6 TMSs in a 1 + 2 + 2 + 1 TMS arrangement. Oxidation of its substrates requires the peroxysomal fatty acyl CoA ligase, suggesting that the free acids are the transported substrates.   

Accession Number:P41909
Protein Name:Peroxisomal long-chain fatty acid import protein 2
Length:870
Molecular Weight:100025.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Peroxisome membrane1 / Multi-pass membrane protein2
Substrate long-chain fatty acid, oleic acid

Cross database links:

DIP: DIP-7809N
Pfam: PF06472    PF00005   

Gene Ontology

GO:0005779 C:integral to peroxisomal membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane movement of substances
GO:0005515 F:protein binding
GO:0015908 P:fatty acid transport

References (5)

[1] “PXA1, a possible Saccharomyces cerevisiae ortholog of the human adrenoleukodystrophy gene.”  Shani N.et.al.   7597071
[2] “The PAL1 gene product is a peroxisomal ATP-binding cassette transporter in the yeast Saccharomyces cerevisiae.”  Swartzman E.E.et.al.   8647887
[3] “The sequence of 55 kb on the left arm of yeast chromosome XVI identifies a small nuclear RNA, a new putative protein kinase and two new putative regulators.”  Purnelle B.et.al.   8948103
[4] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.”  Bussey H.et.al.   9169875
[5] “The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae.”  Hettema E.H.et.al.   8670886

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSTTLAAPAK LKSLLLNLHT HCIGLHVNDV TPKVYFKLLI RHLLQISRSN AAHPKLRRRA 
61:	QILLVSLFLS GVTLFSGVTY STFKIILKCY KFYKFPWKRR NRRPLIRRTR SQMQLDSGAR 
121:	IMYIPEVELV DRQSPDDNKF MNATDKKKRK RIFIPPKDND VYEHDKFLFK NVELERAKNS 
181:	QLFYSKFLNQ MNVLSKILIP TVFDKNFLLL TAQIFFLVMR TWLSLFVAKL DGQIVKNIIA 
241:	GRGRSFLWDL GCWFLIAVPA SYTNSAIKLL QRKLSLNFRV NLTRYIHDMY LDKRLTFYKL 
301:	IFDAKASNSV IKNIDNSITN DVAKFCDATC SVFANIAKPV IDLIFFSVYL RDNLGTVGVA 
361:	GIFVNYFITG FILRKYTPPL GKLAGERSAS DGDYYNYHLN MINNSEEIAF YQGTAVERTK 
421:	VKELYDVLME KMLLVDKVKF GYNMLEDYVL KYTWSGLGYV FASIPIVMST LATGINSEEK 
481:	NMKEFIVNKR LMLSLADAGS RLMHSIKDIS QLTGYTNRIF TLLSVLHRVH SLNFNYGAVP 
541:	SILSIRTEDA SRNSNLLPTT DNSQDAIRGT IQRNFNGIRL ENIDVIIPSV RASEGIKLIN 
601:	KLTFQIPLHI DPITSKSNSI QDLSKANDIK LPFLQGSGSS LLILGPNGCG KSSIQRIIAE 
661:	IWPVYNKNGL LSIPSENNIF FIPQKPYFSR GGTLRDQIIY PMSSDEFFDR GFRDKELVQI 
721:	LVEVKLDYLL KRGVGLTYLD AIADWKDLLS GGEKQRVNFA RIMFHKPLYV VLDEATNAIS 
781:	VDMEDYLFNL LKRYRFNFIS ISQRPTLIKY HEMLLEIGEN RDGKWQLQAV GTDEAITSID 
841:	NEIEELERKL ERVKGWEDER TKLREKLEII