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3.A.1.104.1
Teichoic acid exporter, TagGH.  It is present in a large complex with the teichoic acid precursor synthetic enzymes (Formstone et al. 2008).  The substrate may be the diphospholipid-linked disaccharide portion of the teichoic acid precursor (Schirner et al. 2011).  3-d structural studies have been reported (Ko et al. 2016) showing that TagG and TagH are localized on the cytoplasmic membrane in a patch, and the TMS of TagH is important for normal transport activity (Yamada et al. 2018). The crystal structure of the N-terminal domain of TagH reveals a potential drug targeting site (Yang et al. 2020). The ATPase activity of TagH-N was inhibited by clodronate, a bisphosphonate, in a non-competitive manner, consistent with the proposed wall teichoic acid-binding site for drug targeting (Yang et al. 2020).

Accession Number:P42953
Protein Name:TagG
Length:275
Molecular Weight:32185.00
Species:Bacillus subtilis [1423]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate teichoic acid

Cross database links:

RefSeq: NP_391452.1   
Entrez Gene ID: 936794   
Pfam: PF01061   
KEGG: bsu:BSU35710   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006810 P:transport

References (2)

[1] “The tagGH operon of Bacillus subtilis 168 encodes a two-component ABC transporter involved in the metabolism of two wall teichoic acids.”  Lazarevic V.et.al.   7565096
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNDLLRILRE QITSFPLILR LAAYETKSKY QMNYLGVLWQ FLNPLIQMLA YWFVFGMGIR 
61:	KGGPVTTGAG EVPFIIWMLA GLIPWFFISP TILDGSNSVF KRINMVAKMN FPISSLPSVA 
121:	IASNLFSYMI MMVIYIIVLL VNGVFPSVHW LQYIYYFICM IAFMFSFSLF NSTISVLIRD 
181:	YQFLLQAVTR LLFFLLPIFW DVNAKLGQSH PELVPVLKLN PLFYIIEGFR NSFLDGAWFF 
241:	HDMKYTLYFW LFTFLLLLVG SILHMKFRDK FVDFL