9.A.34.1.1
The nuclear export protein complex, Brr6-Brl1-Apq12 (de Bruyn Kops and Guthrie 2001). Apq12 may be involved
in the regulation of lipid homeostasis in the endoplasmic reticulum,
thereby impacting nuclear pore complex biogenesis and localization, and
nucleocytoplasmic mRNA transport (Lone et al. 2015). Brr6 and the C-terminal 140 aas of Brl1 are homologous. An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae (Kralt et al. 2022).
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| Accession Number: | P53062 |
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| Protein Name: | Nucleus export protein BRR6 |
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| Length: | 197 |
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| Molecular Weight: | 22807.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Nucleus membrane1 / Multi-pass membrane protein2 |
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| Substrate |
messenger RNA |
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1: MELRSFSRQP DGILANPRLG REEVLEGEHP QDARLARQSI WLSPSLIAEY IQLFFNFIIG
61: TIGLSLAIKF ILMIRNDVNL KLEHNVREEL DKIATCKSRY FENQCEPHMR VPALEVRCNE
121: WSKCMNKEIV SGSDYQWAKA WARTLAEVIN AFFEAFSIRS FLFILISIIG IIFVTNTSFG
181: SYRVYLNNKD TKSVRHA