3.A.1.103.10
Wzm (M; 280 aas; 6 or 7 TMSs in a 2 + 3 + 1 or 2 TMS arrangement)-Wzt (C) ABC lipid-linked galactan precursor exporter. Deletion of the encoding genes results in severe morphological changes and the accumulation of an aberrantly long galactan precursor. A model for coupled synthesis and export of the galactanpolymer precursor in mycobacteria has been proposed (Savková et al. 2021). The two encoding genes are separated by a gene that encodes a galactofuranosyltransferase, GlfT1.
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| Accession Number: | P72049 |
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| Protein Name: | Probable O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD |
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| Length: | 280 |
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| Molecular Weight: | 32336.00 |
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| Species: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [83332] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MTFMDAQASF QTQSRTLARV RGDLVDGFRR HELWLHLGWQ DIKQRYRRSV LGPFWITIAT
61: GTTAVAMGGL YSKLFRLELS EHLPYVTLGL IVWNLINAAI LDGAEVFVAN EGLIKQLPAP
121: LSVHVYRLVW RQMIFFAHNI VIYFVIAIIF PKPWSWADLS FLPALALIFL NCVWVSLCFG
181: ILATRYRDIG PLLFSVVQLL FFMTPIIWND ETLRRQGAGR WSSIVELNPL LHYLDIVRAP
241: LLGAHQELRH WLVVLVLTVV GWMLAAFAMR QYRARVPYWV