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1.A.1.5.4 Olfactory heteromeric cyclic nucleotide-gated cation (mainly Na⁺, Ca²⁺) channel CNGA2/CNGA4/CNGB1b (present in sensory cilia of olfactory receptor neurons; activated by odorant-induced increases in cAMP concentration) (Michalakis et al., 2006).
Accession Number:	Q3UW12
Protein Name:	Cyclic nucleotide-gated cation channel alpha-4
Length:	575
Molecular Weight:	65835.00
Species:	[10090]
Number of TMSs:	7
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	calcium(2+), sodium(1+)

RefSeq:	NP_001028489.1
Entrez Gene ID:	233649
Pfam:	PF00027 PF00520
KEGG:	mmu:233649
Gene Ontology GO:0030552 F:cAMP binding GO:0006811 P:ion transport GO:0050896 P:response to stimulus GO:0007608 P:sensory perception of smell GO:0055085 P:transmembrane transport
References (4) [1] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [3] “Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation.” Munger S.D.et.al. 11739959 [4] “Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice.” Kelliher K.R.et.al. 12649326

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSQDSKVKTT ESTPPAPTKA RKWLPVLDPS GDYYYWWLNT MVFPIMYNLI IVVCRACFPD 
61:	LQHSYLVAWF VLDYTSDLLY LLDIGVRFHT GFLEQGILVV DKSMIASRYV RTWSFLLDLA 
121:	SLVPTDAAYV QLGPHIPTLR LNRFLRVPRL FEAFDRTETR TAYPNAFRIA KLMIYIFVVI 
181:	HWNSCLYFAL SRYLGFGRDA WVYPDPAQPG FERLRRQYLY SFYFSTLILT TVGDTPLPAR 
241:	EEEYLFMVGD FLLAVMGFAT IMGSMSSVIY NMNTADAAFY PDHALVKKYM KLQHVNRRLE 
301:	RRVIDWYQHL QINKKMTNEV AILQHLPERL RAEVAVSVHL STLSRVQIFQ NCEASLLEEL 
361:	VLKLQPQTYS PGEYVCRKGD IGREMYIIRE GQLAVVADDG VTQYAVLGAG LYFGEISIIN 
421:	IKGNMSGNRR TANIKSLGYS DLFCLSKEDL REVLSEYPQA QAVMEEKGRE ILLKMNKLDV 
481:	NAEAAEIALQ EATESRLKGL DQQLDDLQTK FARLLAELES SALKIAYRIE RLEWQTREWP 
541:	MPDDMGEADD EAEPGEGTSK DGEEKAGQEG PSGLE

1.A.1.5.4
Olfactory heteromeric cyclic nucleotide-gated cation (mainly Na⁺, Ca²⁺) channel CNGA2/CNGA4/CNGB1b (present in sensory cilia of olfactory receptor neurons; activated by odorant-induced increases in cAMP concentration) (Michalakis et al., 2006).

Cross database links:

Gene Ontology

References (4)

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1.A.1.5.4Olfactory heteromeric cyclic nucleotide-gated cation (mainly Na+, Ca2+) channel CNGA2/CNGA4/CNGB1b (present in sensory cilia of olfactory receptor neurons; activated by odorant-induced increases in cAMP concentration) (Michalakis et al., 2006).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

1.A.1.5.4
Olfactory heteromeric cyclic nucleotide-gated cation (mainly Na⁺, Ca²⁺) channel CNGA2/CNGA4/CNGB1b (present in sensory cilia of olfactory receptor neurons; activated by odorant-induced increases in cAMP concentration) (Michalakis et al., 2006).