9.A.17.1.1
The Pex3/Pex16/Pex19 peroxisomal protein importer (for insertion of integral membranes from the cytosol to the peroxisomal membrane) (Matsuzono and Fujiki, 2006). Pex3 promotes formation of peroxisome-peroxisome and peroxisome-lipid droplet contact sites (Amado et al. 2025). Pex3 is a conserved multifunctional peroxisomal transmembrane protein
that is involved in the insertion of peroxisomal membrane proteins, in
pexophagy, and in the formation of membrane contact sites. High Pex3 levels in Saccharomyces cerevisiae induce the formation
of peroxisome clusters surrounded by lipid droplets, mediated by
peroxisome-peroxisome and peroxisome-lipid droplet contact sites (Amado et al. 2025).
|
| Accession Number: | Q5KG96 |
|---|
| Protein Name: | Peroxisomal membrane protein pex16, putative |
|---|
| Length: | 384 |
|---|
| Molecular Weight: | 43033.00 |
|---|
| Species: | Cryptococcus neoformans (Filobasidiella neoformans) [5207] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell outer membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
protein polypeptide chain |
|---|
1: MSPLEAYHSF LLSNLSAVQT IESSISNITW LLPGRFEDAE VASEGLYALL SLVAGYHDKI
61: LSSHLSSSLS LPPHPFAKPR TPTEPLSASQ ESVTTRIHPL LPPPSDHARY TRYWTESSSL
121: YEKASRALST ISYLELLVEM VARKKLGDRR RWKVVLGLES LKTFLRLLLM LKTRRPVLSQ
181: PTPQREFDLA SVPSEVLDPS SSQPQDGNNP VTPQLPAYSP LRSHLFPMAG NLPEKYLEHP
241: LDLIPQLKGS EYIAEAVACC VGLARIYLLI RTSRQEVTRP YNPSSLPTLS RSMSPYLIPL
301: ALLLLSRRLR SKSESPLLMS HYAQQDKKLA LQAFMTGPMW IGWTRPKIVS VARALERLPI
361: LGLVGDLVEG YLPLVDDYFF YTTS