2.A.6.2.23
The multidrug (β-lactams, aminoglycerides (gentamycin and streptomycin) macrolides (erythromycin) and dye (acriflavin)) efflux pump, BpeAB-OprB (Chan et al., 2004; Chan and Chua, 2005). It also exports acyl homoserine lactones including N-octanoyl-homoserine lactone, N-decanoyl-homoserine lactone, N-(3-hydroxy)-octanoyl-homoserine lactone, N-(3-hydroxy)-decanoyl-homoserine lactone, N-(3-oxo)-decanoyl-homoserine lactone, and N-(3-oxo)-tetradecanoyl-homoserine lactone (Chan et al., 2007). Q9HWH6 is a DoxX family member (see 9.B.214.2).
|
| Accession Number: | Q6VV68 |
|---|
| Protein Name: | BpeB |
|---|
| Length: | 1066 |
|---|
| Molecular Weight: | 114771.00 |
|---|
| Species: | Burkholderia pseudomallei (Pseudomonas pseudomallei) [28450] |
|---|
| Number of TMSs: | 12 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
beta-lactam, streptomycin, gentamycin, erythromycin A, 3,6-diamino-10-methylacridinium chloride, N-acyl homoserine lactone |
|---|
| Pfam: |
PF00873
|
|---|
|
|
[1] “BpeAB-OprB, a multidrug efflux pump in Burkholderia pseudomallei.” Chan Y.Y. et.al. 15047512
|
1: MAKFFIDRPI FAWVIAIILM LAGVAAIFTL PIAQYPTIAP PSIQITANYP GASAKTVEDT
61: VTQVIEQQMS GLDNFLYMSS TSDDSGNATI TITFAPGTNP DIAQVQVQNK LSLATPILPQ
121: VVQQLGLSVT KSSSSFLLVL AFNSEDGSMN KYDLANYVAL HVKDPISRIN GVGTVTLFGS
181: QYAMRIWLDP TKLTNYGLTP VDVTSAISAQ NVQIAGGQLG GTPAVPGTVL QATITEATLL
241: QTPEQFGNIL LKVNQDGSQV RLKDVAQIGL GGETYNFDTK YNGQPTAALG IQLATNANAL
301: ATAKAVRAKI DEMSAYFPHG LVVKYPYDTT PFVRLSIEEV VKTLLEGIVL VFLVMYLFLQ
361: NLRATIIPTI AVPVVLLGTF AIMSMVGFSI NVLSMFGLVL AIGLLVDDAI VVVENVERVM
421: AEEGLPPKEA TRKAMGQITG ALVGVALVLS AVFVPVAFSG GSVGAIYRQF SLTIVSAMVL
481: SVLVALILTP ALCATILKPI PQGHHEEKKG FFGWFNRTFN SSRDKYHVGV HHVIKRSGRW
541: LIIYLAVIVA VGLLFVRLPK SFLPDEDQGL MFVIVQTPSG STQETTARTL ANISDYLLTQ
601: EKDIVESAFT VNGFSFAGRG QNSGLVFVKL KDYSQRQSSD QKVQALIGRM FGRYAGYKDA
661: LVIPFNPPSI PELGTAAGFD FELTDNAGLG HDALMAARNQ LLGMAAKDPT LRGVRPNGLN
721: DTPQYKVDID REKANALGVT ADAIDQTFSI AWASKYVNNF LDTDGRIKKV YVQSDAPFRM
781: TPEDMNIWYV RNGSGGMVPF SAFATGHWTY GSPKLERYNG ISAMEIQGQA APGKSTGQAM
841: TAMETLAKKL PTGIGYSWTG LSFQEIQSGS QAPILYAISI LVVFLCLAAL YESWSIPFSV
901: IMVVPLGVIG ALLAATLRGL ENDVFFQVGL LTTVGLSAKN AILIVEFARE LQQTEKMGPI
961: EAALEAARLR LRPILMTSLA FILGVMPLAI SNGAGSASQH AIGTGVIGGM ITATFLAIFM
1021: IPMFFVKVRA VFSGEKEDAD EALRLAHEHM HRDDKPEHGD DAGKKD