3.A.1.135.9
Multidrug exporter, EfrEF. Mediates efflux of fluorescent substrates and confers resistance towards multiple dyes and drugs including fluoroquinolones (Hürlimann et al. 2016).
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| Accession Number: | Q832J9 |
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| Protein Name: | ABC transporter, ATP-binding/permease protein |
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| Length: | 592 |
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| Molecular Weight: | 65881.00 |
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| Species: | Enterococcus faecalis (strain ATCC 700802 / V583) [226185] |
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| Number of TMSs: | 5 |
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| Substrate |
fluoroquinolone antibiotic, drug |
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1: MKKTMNLQSF KRFWKMIKPE HPIFYGLMIC SLIGNLLIVA MTYIMAIGID NLLEAIKRVG
61: LKGMTLPLVE EALLGPVLLL ILFSIISSIT SFIQERAMAS LSERVTLRIR KEVTKKFKTL
121: PMAFFDNHQV GDIISRSTTG LNQLSQVLLT GINQFFTSVV TILFAGIMLF YIDAKLTILV
181: LLLIGGSTFM TTKIANKNKV FADQSQAELG QLNNKMEEYL AGNLVTKTFN QQQNAEKTID
241: AVNQQHYRAF KKAQFLNFAI YPAIRFINQL AFIISAILGA MLVLSGGITI GFLQAYLQYI
301: NQISEPISTA SYVINSIQAA MASIDRIFVI LDEADEQPEA THLETISSPK GAIEFKNVQF
361: GYTPEKILMK NVDFSVQPKK TVAIVGPTGA GKTTLVNLLM RFYEINQGAI TFDGIDITKL
421: SRQNLRNLFG MVLQNTWLFE GTVADNIAYG KKDASREEII EAAKIAQCDH FIRTLPQGYD
481: TIISSENGAL SQGQQQLLTI ARIILANPPV VILDEATSSV DTRTEAHIQK AMETVTENRT
541: SFVIAHRLST IENADLILVM KNGDIIEKGT HQELLQAPTL YASLYNSQFQ TT