9.B.325.1.1
The putative two component ABC-4-type transporter (Rafii and Park, 2008). It appears to transport multiple drugs including ethidium and fluoroquinolones. The membrane protein (Q83XH0) is N-terminally truncked and is missing 88 aas. A full length protein is R5TMA6 with 451 aas and 10 TMSs in a 5 + 5 TMS arrangement. This membrane protein has replaced the former one in this TC entry.
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| Accession Number: | Q83XH1 |
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| Protein Name: | CmpA |
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| Length: | 546 |
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| Molecular Weight: | 62090.00 |
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| Species: | Clostridium hathewayi [154046] |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
fluoroquinolone antibiotic, ethidium, drug |
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| Pfam: |
PF00005
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[1] “Detection and characterization of an ABC transporter in Clostridium hathewayi.” Rafii F. et.al. 18504552
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1: MIGVNNVTLR IGKKALFEDV NIKFTEGNCY GMIGANGAGK STFLRILSGQ LEPTSGDIVM
61: TPGQRLSFLQ QDHFKYDEYQ VLDTVIMGNA RLYEIMKEKD AIYMKEEFTD EDGIKAAELE
121: GEFASMDGWE AESDAANLLN GLGIETEFHY KYMKELNGAQ KVKVLLAQAL FGNPDILLLD
181: EPTNHLDLDA IAWLEEFLIN FENTVIVVSH DRYFLNKVCT QIADIDYGKI QLYAGNYDFW
241: YESSQLMVKQ MKEANRKKEE KIKELQEFIQ RFSANASKSK QATSRKRALE KIELDDIKPS
301: SRKYPYIDFR PAREIGNEVL TVQNLSKTID GVKVLDNISF TLNREDKVAL VGPNEQAKTV
361: LFKILSGEME PDEGDYKWGL TTSQCYFPKD NSAEFNNDDT IVDWLTQYSP EKEATYVRGF
421: LGRMLFAGED GVKKVRVLSG GEKVRCMLSK LMISGANVLM LDEPTDHLDM ESITALNNGL
481: VKFQGVLLFS SRDHQIVETT ANRIMEIVNG QLIDKITTYD EYLASDEMAR KRQVFTLTDE
541: QMQENE