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2.A.6.2.19
The multidrug efflux pump, EefABC (exports chloramphenicol, ciprofloxacin, erythromycin, tetracycline and doxycycline) (Masi et al., 2005). EefC exhibits low ionic selectivity (Masi et al., 2007).

Accession Number:Q8GC82
Protein Name:EefC outer membrane protein
Length:454
Molecular Weight:48208.00
Species:Enterobacter aerogenes (Aerobacter aerogenes) [548]
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ion, ciprofloxacin, chloramphenicol, tetracycline, doxycycline, erythromycin A

Cross database links:

Pfam: PF02321   

Gene Ontology

GO:0016020 C:membrane
GO:0008289 F:lipid binding
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “The eefABC multidrug efflux pump operon is repressed by H-NS in Enterobacter aerogenes.”  Masi M.et.al.   15901719

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MFRLSLMFIA LLTAGCVSLD PHYERPAAPV PATLPGAHGE STAVVGDWQK VVNDARLKKV 
61:	VSIALNSNRD VQKALADIEA ARAQYGETRA SLFPTVDAEL SHTRSKTIAS GLSSTSQADG 
121:	AVSSFELDLF GKNQSLSRAA RESWLASEFT AQNTRLTMIA DLTTAWVTLA TDNSNLALAQ 
181:	QTMDSAENSR KIVARQMAVG TASAGDLSSA ESVYQQARAS VASYRTLVAQ DKNAINLLAG 
241:	ETVPESLLPG TLESLGDNSI TLVPAGVSSS VLLRRPDIQE AEHNLKSANA DIGAARANFF 
301:	PSISLTASAG VGSDSLSSLF SHGMQVWSFA PSISLPLFTG GSNLAQLRYA QAEKKGLIAT 
361:	YEKSIQSAFK DVADALARRE TLSEQLDAQQ QYVAAEQKSL DIAMKSYQAG VGDYLSVLTA 
421:	QRTLWSAKAT LLSLQQTDLN NRITLWQSLG GGAS