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1.A.1.11.15
Neuronal nonselective cation channel, NALCN (forms background leak conductance and controls neuronal excitability; Lu et al., 2007).  It is also found in the pancreatic β-cell (Swayne et al. 2010). NALCN serves as a variable sensor that responds to calcium or sodium ion flux, depending on whether the total cellular current density is generated more from calcium-selective or sodium-selective channels (Senatore and Spafford 2013). It functions in a complex with Unc80 (3258 aas; Q8N2C7) and Unc79 (2635 aas; Q9P2D8) (Bramswig et al. 2018). Heterozygous de novo NALCN missense variants in the S5/S6 pore-forming segments lead to congenital contractures of the limbs and face, hypotonia, and developmental delay (Bramswig et al. 2018). Overexpression of the NALCN gene ablates allyl isothiocyanate-promoting pain reception by nociceptors (Eigenbrod et al. 2019).

Accession Number:Q8N2C7
Protein Name:Protein unc-80 homolog
Length:3258
Molecular Weight:363390.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cation

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVKRKSSEGQ EQDGGRGIPL PIQTFLWRQT SAFLRPKLGK QYEASCVSFE RVLVENKLHG 
61:	LSPALSEAIQ SISRWELVQA ALPHVLHCTA TLLSNRNKLG HQDKLGVAET KLLHTLHWML 
121:	LEAPQDCNNE RFGGTDRGSS WGGSSSAFIH QVENQGSPGQ PCQSSSNDEE ENNRRKIFQN 
181:	SMATVELFVF LFAPLVHRIK ESDLTFRLAS GLVIWQPMWE HRQPGVSGFT ALVKPIRNII 
241:	TAKRSSPINS QSRTCESPNQ DARHLEGLQV VCETFQSDSI SPKATISGCH RGNSFDGSLS 
301:	SQTSQERGPS HSRASLVIPP CQRSRYATYF DVAVLRCLLQ PHWSEEGTQW SLMYYLQRLR 
361:	HMLEEKPEKP PEPDIPLLPR PRSSSMVAAA PSLVNTHKTQ DLTMKCNEEE KSLSSEAFSK 
421:	VSLTNLRRSA VPDLSSDLGM NIFKKFKSRK EDRERKGSIP FHHTGKRRPR RMGVPFLLHE 
481:	DHLDVSPTRS TFSFGSFSGL GEDRRGIEKG GWQTTILGKL TRRGSSDAAT EMESLSARHS 
541:	HSHHTLVSDL PDPSNSHGEN TVKEVRSQIS TITVATFNTT LASFNVGYAD FFNEHMRKLC 
601:	NQVPIPEMPH EPLACANLPR SLTDSCINYS YLEDTEHIDG TNNFVHKNGM LDLSVVLKAV 
661:	YLVLNHDISS RICDVALNIV ECLLQLGVVP CVEKNRKKSE NKENETLEKR PSEGAFQFKG 
721:	VSGSSTCGFG GPAVSGAGDG GGEEGGGGDG GGGGGDGGGG GGGGGGPYEK NDKNQEKDES 
781:	TPVSNHRLAL TMLIKIVKSL GCAYGCGEGH RGLSGDRLRH QVFRENAQNC LTKLYKLDKM 
841:	QFRQTMRDYV NKDSLNNVVD FLHALLGFCM EPVTDNKAGF GNNFTTVDNK STAQNVEGII 
901:	VSAMFKSLIT RCASTTHELH SPENLGLYCD IRQLVQFIKE AHGNVFRRVA LSALLDSAEK 
961:	LAPGKKVEEN EQESKPAGSK RSEAGSIVDK GQVSSAPEEC RSFMSGRPSQ TPEHDEQMQG 
1021:	ANLGRKDFWR KMFKSQSAAS DTSSQSEQDT SECTTAHSGT TSDRRARSRS RRISLRKKLK 
1081:	LPIGKRNWLK RSSLSGLADG VEDLLDISSV DRLSFIRQSS KVKFTSAVKL SEGGPGSGME 
1141:	NGRDEEENFF KRLGCHSFDD HLSPNQDGGK SKNVVNLGAI RQGMKRFQFL LNCCEPGTIP 
1201:	DASILAAALD LEAPVVARAA LFLECARFVH RCNRGNWPEW MKGHHVNITK KGLSRGRSPI 
1261:	VGNKRNQKLQ WNAAKLFYQW GDAIGVRLNE LCHGESESPA NLLGLIYDEE TKRRLRKEDE 
1321:	EEDFLDDSTV NPSKCGCPFA LKMAACQLLL EITTFLRETF SCLPRPRTEP LVDLESCRLR 
1381:	LDPELDRHRY ERKISFAGVL DENEDSKDSL HSSSHTLKSD AGVEEKKEGS PWSASEPSIE 
1441:	PEGMSNAGAE ENYHRNMSWL HVMILLCNQQ SFICTHVDYC HPHCYLHHSR SCARLVRAIK 
1501:	LLYGDSVDSL RESSNISSVA LRGKKQKECS DKSCLRTPSL KKRVSDANLE GKKDSGMLKY 
1561:	IRLQVMSLSP APLSLLIKAA PILTEEMYGD IQPAAWELLL SMDEHMAGAA AAMFLLCAVK 
1621:	VPEAVSDMLM SEFHHPETVQ RLNAVLKFHT LWRFRYQVWP RMEEGAQQIF KIPPPSINFT 
1681:	LPSPVLGMPS VPMFDPPWVP QCSGSVQDPI NEDQSKSFSA RAVSRSHQRA EHILKNLQQE 
1741:	EEKKRLGREA SLITAIPITQ EACYEPTCTP NSEPEEEVEE VTNLASRRLS VSPSCTSSTS 
1801:	HRNYSFRRGS VWSVRSAVSA EDEEHTTEHT PNHHVPQPPQ AVFPACICAA VLPIVHLMED 
1861:	GEVREDGVAV SAVAQQVLWN CLIEDPSTVL RHFLEKLTIS NRQDELMYML RKLLLNIGDF 
1921:	PAQTSHILFN YLVGLIMYFV RTPCEWGMDA ISATLTFLWE VVGYVEGLFF KDLKQTMKKE 
1981:	QCEVKLLVTA SMPGTKTLVV HGQNECDIPT QLPVHEDTQF EALLKECLEF FNIPESQSTH 
2041:	YFLMDKRWNL IHYNKTYVRD IYPFRRSVSP QLNLVHMHPE KGQELIQKQV FTRKLEEVGR 
2101:	VLFLISLTQK IPTAHKQSHV SMLQEDLLRL PSFPRSAIDA EFSLFSDPQA GKELFGLDTL 
2161:	QKSLWIQLLE EMFLGMPSEF PWGDEIMLFL NVFNGALILH PEDSALLRQY AATVINTAVH 
2221:	FNHLFSLSGY QWILPTMLQV YSDYESNPQL RQAIEFACHQ FYILHRKPFV LQLFASVAPL 
2281:	LEFPDAANNG PSKGVSAQCL FDLLQSLEGE TTDILDILEL VKAEKPLKSL DFCYGNEDLT 
2341:	FSISEAIKLC VTVVAYAPES FRSLQMLMVL EALVPCYLQK LKRQTSQVET VPAAREEIAA 
2401:	TAALATSLQA LLYSVEVLTR PMTAPQMSRC DQGHKGTTTA NHTMSSGVNT RYQEQGAKLH 
2461:	FIRENLHLLE EGQGIPREEL DERIAREEFR RPRESLLNIC TEFYKHCGPR LKILQNLAGE 
2521:	PRVIALELLD VKSHMRLAEI AHSLLKLAPY DTQTMESRGL RRYIMEMLPI TDWTAEAVRP 
2581:	ALILILKRLD RMFNKIHKMP TLRRQVEWEP ASNLIEGVCL TLQRQPIISF LPHLRSLINV 
2641:	CVNLVMGVVG PSSVADGLPL LHLSPYLSPP LPFSTAVVRL VALQIQALKE DFPLSHVISP 
2701:	FTNQERREGM LLNLLIPFVL TVGSGSKDSP WLEQPEVQLL LQTVINVLLP PRIISTSRSK 
2761:	NFMLESSPAH CSTPGDAGKD LRREGLAEST SQAAYLALKV ILVCFERQLG SQWYWLSLQV 
2821:	KEMALRKVGG LALWDFLDFI VRTRIPIFVL LRPFIQCKLL AQPAENHEEL SARQHIADQL 
2881:	ERRFIPRPLC KSSLIAEFNS ELKILKEAVH SGSAYQGKTS ISTVGTSTSA YRLSLATMSR 
2941:	SNTGTGTVWE QDSEPSQQAS QDTLSRTDEE DEENDSISMP SVVSEQEAYL LSAIGRRRFS 
3001:	SHVSSMSVPQ AEVGMLPSQS EPNVLDDSQG LAAEGSLSRV ASIQSEPGQQ NLLVQQPLGR 
3061:	KRGLRQLRRP LLSRQKTQTE PRNRQGARLS TTRRSIQPKT KPSADQKRSV TFIEAQPEPA 
3121:	AAPTDALPAT GQLQGCSPAP SRKPEAMDEP VLTSSPAIVV ADLHSVSPKQ SENFPTEEGE 
3181:	KEEDTEAQGA TAHSPLSAQL SDPDDFTGLE TSSLLQHGDT VLHISEENGM ENPLLSSQFT 
3241:	FTPTELGKTD AVLDESHV