1.A.1.11.15
Neuronal nonselective cation channel, NALCN (forms background leak conductance and controls neuronal excitability; Lu et al., 2007). It is also found in the pancreatic β-cell (Swayne et al. 2010). NALCN serves as a variable
sensor that responds to calcium or sodium ion flux, depending on whether the total cellular current
density is generated more from calcium-selective or sodium-selective channels (Senatore and Spafford 2013). It functions in a complex with Unc80 (3258 aas; Q8N2C7) and Unc79 (2635 aas; Q9P2D8) (Bramswig et al. 2018). Heterozygous de novo NALCN missense variants in the S5/S6 pore-forming
segments lead to congenital contractures of the limbs and face,
hypotonia, and developmental delay (Bramswig et al. 2018). Overexpression of the NALCN gene ablates allyl isothiocyanate-promoting pain reception by nociceptors (Eigenbrod et al. 2019).
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| Accession Number: | Q8N2C7 |
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| Protein Name: | Protein unc-80 homolog |
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| Length: | 3258 |
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| Molecular Weight: | 363390.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cation |
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1: MVKRKSSEGQ EQDGGRGIPL PIQTFLWRQT SAFLRPKLGK QYEASCVSFE RVLVENKLHG
61: LSPALSEAIQ SISRWELVQA ALPHVLHCTA TLLSNRNKLG HQDKLGVAET KLLHTLHWML
121: LEAPQDCNNE RFGGTDRGSS WGGSSSAFIH QVENQGSPGQ PCQSSSNDEE ENNRRKIFQN
181: SMATVELFVF LFAPLVHRIK ESDLTFRLAS GLVIWQPMWE HRQPGVSGFT ALVKPIRNII
241: TAKRSSPINS QSRTCESPNQ DARHLEGLQV VCETFQSDSI SPKATISGCH RGNSFDGSLS
301: SQTSQERGPS HSRASLVIPP CQRSRYATYF DVAVLRCLLQ PHWSEEGTQW SLMYYLQRLR
361: HMLEEKPEKP PEPDIPLLPR PRSSSMVAAA PSLVNTHKTQ DLTMKCNEEE KSLSSEAFSK
421: VSLTNLRRSA VPDLSSDLGM NIFKKFKSRK EDRERKGSIP FHHTGKRRPR RMGVPFLLHE
481: DHLDVSPTRS TFSFGSFSGL GEDRRGIEKG GWQTTILGKL TRRGSSDAAT EMESLSARHS
541: HSHHTLVSDL PDPSNSHGEN TVKEVRSQIS TITVATFNTT LASFNVGYAD FFNEHMRKLC
601: NQVPIPEMPH EPLACANLPR SLTDSCINYS YLEDTEHIDG TNNFVHKNGM LDLSVVLKAV
661: YLVLNHDISS RICDVALNIV ECLLQLGVVP CVEKNRKKSE NKENETLEKR PSEGAFQFKG
721: VSGSSTCGFG GPAVSGAGDG GGEEGGGGDG GGGGGDGGGG GGGGGGPYEK NDKNQEKDES
781: TPVSNHRLAL TMLIKIVKSL GCAYGCGEGH RGLSGDRLRH QVFRENAQNC LTKLYKLDKM
841: QFRQTMRDYV NKDSLNNVVD FLHALLGFCM EPVTDNKAGF GNNFTTVDNK STAQNVEGII
901: VSAMFKSLIT RCASTTHELH SPENLGLYCD IRQLVQFIKE AHGNVFRRVA LSALLDSAEK
961: LAPGKKVEEN EQESKPAGSK RSEAGSIVDK GQVSSAPEEC RSFMSGRPSQ TPEHDEQMQG
1021: ANLGRKDFWR KMFKSQSAAS DTSSQSEQDT SECTTAHSGT TSDRRARSRS RRISLRKKLK
1081: LPIGKRNWLK RSSLSGLADG VEDLLDISSV DRLSFIRQSS KVKFTSAVKL SEGGPGSGME
1141: NGRDEEENFF KRLGCHSFDD HLSPNQDGGK SKNVVNLGAI RQGMKRFQFL LNCCEPGTIP
1201: DASILAAALD LEAPVVARAA LFLECARFVH RCNRGNWPEW MKGHHVNITK KGLSRGRSPI
1261: VGNKRNQKLQ WNAAKLFYQW GDAIGVRLNE LCHGESESPA NLLGLIYDEE TKRRLRKEDE
1321: EEDFLDDSTV NPSKCGCPFA LKMAACQLLL EITTFLRETF SCLPRPRTEP LVDLESCRLR
1381: LDPELDRHRY ERKISFAGVL DENEDSKDSL HSSSHTLKSD AGVEEKKEGS PWSASEPSIE
1441: PEGMSNAGAE ENYHRNMSWL HVMILLCNQQ SFICTHVDYC HPHCYLHHSR SCARLVRAIK
1501: LLYGDSVDSL RESSNISSVA LRGKKQKECS DKSCLRTPSL KKRVSDANLE GKKDSGMLKY
1561: IRLQVMSLSP APLSLLIKAA PILTEEMYGD IQPAAWELLL SMDEHMAGAA AAMFLLCAVK
1621: VPEAVSDMLM SEFHHPETVQ RLNAVLKFHT LWRFRYQVWP RMEEGAQQIF KIPPPSINFT
1681: LPSPVLGMPS VPMFDPPWVP QCSGSVQDPI NEDQSKSFSA RAVSRSHQRA EHILKNLQQE
1741: EEKKRLGREA SLITAIPITQ EACYEPTCTP NSEPEEEVEE VTNLASRRLS VSPSCTSSTS
1801: HRNYSFRRGS VWSVRSAVSA EDEEHTTEHT PNHHVPQPPQ AVFPACICAA VLPIVHLMED
1861: GEVREDGVAV SAVAQQVLWN CLIEDPSTVL RHFLEKLTIS NRQDELMYML RKLLLNIGDF
1921: PAQTSHILFN YLVGLIMYFV RTPCEWGMDA ISATLTFLWE VVGYVEGLFF KDLKQTMKKE
1981: QCEVKLLVTA SMPGTKTLVV HGQNECDIPT QLPVHEDTQF EALLKECLEF FNIPESQSTH
2041: YFLMDKRWNL IHYNKTYVRD IYPFRRSVSP QLNLVHMHPE KGQELIQKQV FTRKLEEVGR
2101: VLFLISLTQK IPTAHKQSHV SMLQEDLLRL PSFPRSAIDA EFSLFSDPQA GKELFGLDTL
2161: QKSLWIQLLE EMFLGMPSEF PWGDEIMLFL NVFNGALILH PEDSALLRQY AATVINTAVH
2221: FNHLFSLSGY QWILPTMLQV YSDYESNPQL RQAIEFACHQ FYILHRKPFV LQLFASVAPL
2281: LEFPDAANNG PSKGVSAQCL FDLLQSLEGE TTDILDILEL VKAEKPLKSL DFCYGNEDLT
2341: FSISEAIKLC VTVVAYAPES FRSLQMLMVL EALVPCYLQK LKRQTSQVET VPAAREEIAA
2401: TAALATSLQA LLYSVEVLTR PMTAPQMSRC DQGHKGTTTA NHTMSSGVNT RYQEQGAKLH
2461: FIRENLHLLE EGQGIPREEL DERIAREEFR RPRESLLNIC TEFYKHCGPR LKILQNLAGE
2521: PRVIALELLD VKSHMRLAEI AHSLLKLAPY DTQTMESRGL RRYIMEMLPI TDWTAEAVRP
2581: ALILILKRLD RMFNKIHKMP TLRRQVEWEP ASNLIEGVCL TLQRQPIISF LPHLRSLINV
2641: CVNLVMGVVG PSSVADGLPL LHLSPYLSPP LPFSTAVVRL VALQIQALKE DFPLSHVISP
2701: FTNQERREGM LLNLLIPFVL TVGSGSKDSP WLEQPEVQLL LQTVINVLLP PRIISTSRSK
2761: NFMLESSPAH CSTPGDAGKD LRREGLAEST SQAAYLALKV ILVCFERQLG SQWYWLSLQV
2821: KEMALRKVGG LALWDFLDFI VRTRIPIFVL LRPFIQCKLL AQPAENHEEL SARQHIADQL
2881: ERRFIPRPLC KSSLIAEFNS ELKILKEAVH SGSAYQGKTS ISTVGTSTSA YRLSLATMSR
2941: SNTGTGTVWE QDSEPSQQAS QDTLSRTDEE DEENDSISMP SVVSEQEAYL LSAIGRRRFS
3001: SHVSSMSVPQ AEVGMLPSQS EPNVLDDSQG LAAEGSLSRV ASIQSEPGQQ NLLVQQPLGR
3061: KRGLRQLRRP LLSRQKTQTE PRNRQGARLS TTRRSIQPKT KPSADQKRSV TFIEAQPEPA
3121: AAPTDALPAT GQLQGCSPAP SRKPEAMDEP VLTSSPAIVV ADLHSVSPKQ SENFPTEEGE
3181: KEEDTEAQGA TAHSPLSAQL SDPDDFTGLE TSSLLQHGDT VLHISEENGM ENPLLSSQFT
3241: FTPTELGKTD AVLDESHV