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2.A.6.2.11
Solvent and antibiotic efflux pump, TtgGHI (SrpABC) (Kieboom et al. 1998; Terán et al., 2007) (solvents extruded include toluene, styrene, m-xylene, ethylbenzene and propylbenzene) (Teran et al., 2007). TtgGHI is the same as SrpABC (Kieboom et al., 1998)

Accession Number:Q93PU5
Protein Name:TtgG
Length:391
Molecular Weight:42588.00
Species:Pseudomonas putida [303]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Lipid-anchor2
Substrate styrene, m-xylene, toluene, ethylbenzene, propylbenzene

Cross database links:

Pfam: PF00529   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0008565 F:protein transporter activity
GO:0009306 P:protein secretion

References (2)

[1] “Three efflux pumps are required to provide efficient tolerance to toluene in Pseudomonas putida DOT-T1E.”  Rojas A.et.al.   11395460
[2] “In vivo and in vitro evidence that TtgV is the specific regulator of the TtgGHI multidrug and solvent efflux pump of Pseudomonas putida.”  Rojas A.et.al.   12896994

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRAERWSQTV RQIRSPRALR VIPLTALMLI SGCGEKEQVS SATPPPDVGV YTVRAQALTL 
61:	TTDLPGRTSA FRVAEVRPQV SGILQKRSFV EGAEVKLGQQ LYQIDPRTYE AQLRRAEANR 
121:	TSAQNLARRY ETLLKTKAVS KQQYDDALAA WKQAEADYQV ARIDVQYTRV LSPISGRIGR 
181:	STVTEGALVT NGQAQSLATV TQLDPIYVDV TQPITKLLGL HKALESGRLQ KTGENQAEVS 
241:	LTLDDGSAYP LPGTLKFSEV SCDPTTGSVT LRAEFPNPNR KLLPGMFVHA LLKEGVQNAA 
301:	ILVPQQAISR DTRGVPSVWV MKADNTVESR EIQTLRTVGN AWLISNGVTE GERIITEGVQ 
361:	RVRSGIAVNA VEAKNVNLVD GFAATTEASA N