1.A.1.11.15
Neuronal nonselective cation channel, NALCN (forms background leak conductance and controls neuronal excitability; Lu et al., 2007). It is also found in the pancreatic β-cell (Swayne et al. 2010). NALCN serves as a variable
sensor that responds to calcium or sodium ion flux, depending on whether the total cellular current
density is generated more from calcium-selective or sodium-selective channels (Senatore and Spafford 2013). It functions in a complex with Unc80 (3258 aas; Q8N2C7) and Unc79 (2635 aas; Q9P2D8) (Bramswig et al. 2018). Heterozygous de novo NALCN missense variants in the S5/S6 pore-forming
segments lead to congenital contractures of the limbs and face,
hypotonia, and developmental delay (Bramswig et al. 2018). Overexpression of the NALCN gene ablates allyl isothiocyanate-promoting pain reception by nociceptors (Eigenbrod et al. 2019).
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| Accession Number: | Q9P2D8 |
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| Protein Name: | Protein unc-79 homolog |
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| Length: | 2635 |
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| Molecular Weight: | 295326.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cation |
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1: MSTKAEQFAS KIRYLQEYHN RVLHNIYPVP SGTDIANTLK YFSQTLLSIL SRTGKKENQD
61: ASNLTVPMTM CLFPVPFPLT PSLRPQVSSI NPTVTRSLLY SVLRDAPSER GPQSRDAQLS
121: DYPSLDYQGL YVTLVTLLDL VPLLQHGQHD LGQSIFYTTT CLLPFLNDDI LSTLPYTMIS
181: TLATFPPFLH KDIIEYLSTS FLPMAILGSS RREGVPAHVN LSASSMLMIA MQYTSNPVYH
241: CQLLECLMKY KQEVWKDLLY VIAYGPSQVK PPAVQMLFHY WPNLKPPGAI SEYRGLQYTA
301: WNPIHCQHIE CHNAINKPAV KMCIDPSLSV ALGDKPPPLY LCEECSERIA GDHSEWLIDV
361: LLPQAEISAI CQKKNCSSHV RRAVVTCFSA GCCGRHGNRP VRYCKRCHSN HHSNEVGAAA
421: ETHLYQTSPP PINTRECGAE ELVCAVEAVI SLLKEAEFHA EQREHELNRR RQLGLSSSHH
481: SLDNADFDNK DDDKHDQRLL SQFGIWFLVS LCTPSENTPT ESLARLVAMV FQWFHSTAYM
541: MDDEVGSLVE KLKPQFVTKW LKTVCDVRFD VMVMCLLPKP MEFARVGGYW DKSCSTVTQL
601: KEGLNRILCL IPYNVINQSV WECIMPEWLE AIRTEVPDNQ LKEFREVLSK MFDIELCPLP
661: FSMEEMFGFI SCRFTGYPSS VQEQALLWLH VLSELDIMVP LQLLISMFSD GVNSVKELAN
721: QRKSRVSELA GNLASRRVSV ASDPGRRVQH NMLSPFHSPF QSPFRSPLRS PFRSPFKNFG
781: HPGGRTIDFD CEDDEMNLNC FILMFDLLLK QMELQDDGIT MGLEHSLSKD IISIINNVFQ
841: APWGGSHTCQ KDEKAIECNL CQSSILCYQL ACELLERLAP KEESRLVEPT DSLEDSLLSS
901: RPEFIIGPEG EEEENPASKH GENPGNCTEP VEHAAVKNDT ERKFCYQQLP VTLRLIYTIF
961: QEMAKFEEPD ILFNMLNCLK ILCLHGECLY IARKDHPQFL AYIQDHMLIA SLWRVVKSEF
1021: SQLSSLAVPL LLHALSLPHG ADIFWTIING NFNSKDWKMR FEAVEKVAVI CRFLDIHSVT
1081: KNHLLKYSLA HAFCCFLTAV EDVNPAVATR AGLLLDTIKR PALQGLCLCL DFQFDTVVKD
1141: RPTILSKLLL LHFLKQDIPA LSWEFFVNRF ETLSLEAQLH LDCNKEFPFP TTITAVRTNV
1201: ANLSDAALWK IKRARFARNR QKSVRSLRDS VKGPVESKRA LSLPETLTSK IRQQSPENDN
1261: TIKDLLPEDA GIDHQTVHQL ITVLMKFMAK DESSAESDIS SAKAFNTVKR HLYVLLGYDQ
1321: QEGCFMIAPQ KMRLSTCFNA FIAGIAQVMD YNINLGKHLL PLVVQVLKYC SCPQLRHYFQ
1381: QPPRCSLWSL KPHIRQMWLK ALLVILYKYP YRDCDISKIL LHLIHITVNT LNAQYHSCKP
1441: HATAGPLYSD NSNISRYSEK EKGEIELAEY RETGALQDSL LHCVREESIP KKKLRSFKQK
1501: SLDIGNADSL LFTLDEHRRK SCIDRCDIEK PPTQAAYIAQ RPNDPGRSRQ NSATRPDNSE
1561: IPENPAMEGF PDARRPVIPE VRLNCMETFE VKVDSPVKPA PKEDLDLIDL SSDSTSGPEK
1621: HSILSTSDSD SLVFEPLPPL RIVESDEEEE TMNQGDDGPS GKNAASSPSV PSHPSVLSLS
1681: TAPLVQVSVE DCSKDFSSKD SGNNQSAGNT DSALITLEDP MDAEGSSKPE ELPEFSCGSP
1741: LTLKQKRDLL QKSFALPEMS LDDHPDPGTE GEKPGELMPS SGAKTVLLKV PEDAENPTES
1801: EKPDTSAESD TEQNPERKVE EDGAEESEFK IQIVPRQRKQ RKIAVSAIQR EYLDISFNIL
1861: DKLGEQKDPD PSTKGLSTLE MPRESSSAPT LDAGVPETSS HSSISTQYRQ MKRGSLGVLT
1921: MSQLMKRQLE HQSSAPHNIS NWDTEQIQPG KRQCNVPTCL NPDLEGQPLR MRGATKSSLL
1981: SAPSIVSMFV PAPEEFTDEQ PTVMTDKCHD CGAILEEYDE ETLGLAIVVL STFIHLSPDL
2041: AAPLLLDIMQ SVGRLASSTT FSNQAESMMV PGNAAGVAKQ FLRCIFHQLA PNGIFPQLFQ
2101: STIKDGTFLR TLASSLMDFN ELSSIAALSQ LLEGLNNKKN LPAGGAMIRC LENIATFMEA
2161: LPMDSPSSLW TTISNQFQTF FAKLPCVLPL KCSLDSSLRI MICLLKIPST NATRSLLEPF
2221: SKLLSFVIQN AVFTLAYLVE LCGLCYRAFT KERDKFYLSR SVVLELLQAL KLKSPLPDTN
2281: LLLLVQFICA DAGTKLAEST ILSKQMIASV PGCGTAAMEC VRQYINEVLD FMADMHTLTK
2341: LKSHMKTCSQ PLHEDTFGGH LKVGLAQIAA MDISRGNHRD NKAVIRYLPW LYHPPSAMQQ
2401: GPKEFIECVS HIRLLSWLLL GSLTHNAVCP NASSPCLPIP LDAGSHVADH LIVILIGFPE
2461: QSKTSVLHMC SLFHAFIFAQ LWTVYCEQSA VATNLQNQNE FSFTAILTAL EFWSRVTPSI
2521: LQLMAHNKVM VEMVCLHVIS LMEALQECNS TIFVKLIPMW LPMIQSNIKH LSAGLQLRLQ
2581: AIQNHVNHHS LRTLPGSGQS SAGLAALRKW LQCTQFKMAQ VEIQSSEAAS QFYPL