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1.A.1.11.15
Neuronal nonselective cation channel, NALCN (forms background leak conductance and controls neuronal excitability; Lu et al., 2007).  It is also found in the pancreatic β-cell (Swayne et al. 2010). NALCN serves as a variable sensor that responds to calcium or sodium ion flux, depending on whether the total cellular current density is generated more from calcium-selective or sodium-selective channels (Senatore and Spafford 2013). It functions in a complex with Unc80 (3258 aas; Q8N2C7) and Unc79 (2635 aas; Q9P2D8) (Bramswig et al. 2018). Heterozygous de novo NALCN missense variants in the S5/S6 pore-forming segments lead to congenital contractures of the limbs and face, hypotonia, and developmental delay (Bramswig et al. 2018). Overexpression of the NALCN gene ablates allyl isothiocyanate-promoting pain reception by nociceptors (Eigenbrod et al. 2019).

Accession Number:Q9P2D8
Protein Name:Protein unc-79 homolog
Length:2635
Molecular Weight:295326.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cation

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTKAEQFAS KIRYLQEYHN RVLHNIYPVP SGTDIANTLK YFSQTLLSIL SRTGKKENQD 
61:	ASNLTVPMTM CLFPVPFPLT PSLRPQVSSI NPTVTRSLLY SVLRDAPSER GPQSRDAQLS 
121:	DYPSLDYQGL YVTLVTLLDL VPLLQHGQHD LGQSIFYTTT CLLPFLNDDI LSTLPYTMIS 
181:	TLATFPPFLH KDIIEYLSTS FLPMAILGSS RREGVPAHVN LSASSMLMIA MQYTSNPVYH 
241:	CQLLECLMKY KQEVWKDLLY VIAYGPSQVK PPAVQMLFHY WPNLKPPGAI SEYRGLQYTA 
301:	WNPIHCQHIE CHNAINKPAV KMCIDPSLSV ALGDKPPPLY LCEECSERIA GDHSEWLIDV 
361:	LLPQAEISAI CQKKNCSSHV RRAVVTCFSA GCCGRHGNRP VRYCKRCHSN HHSNEVGAAA 
421:	ETHLYQTSPP PINTRECGAE ELVCAVEAVI SLLKEAEFHA EQREHELNRR RQLGLSSSHH 
481:	SLDNADFDNK DDDKHDQRLL SQFGIWFLVS LCTPSENTPT ESLARLVAMV FQWFHSTAYM 
541:	MDDEVGSLVE KLKPQFVTKW LKTVCDVRFD VMVMCLLPKP MEFARVGGYW DKSCSTVTQL 
601:	KEGLNRILCL IPYNVINQSV WECIMPEWLE AIRTEVPDNQ LKEFREVLSK MFDIELCPLP 
661:	FSMEEMFGFI SCRFTGYPSS VQEQALLWLH VLSELDIMVP LQLLISMFSD GVNSVKELAN 
721:	QRKSRVSELA GNLASRRVSV ASDPGRRVQH NMLSPFHSPF QSPFRSPLRS PFRSPFKNFG 
781:	HPGGRTIDFD CEDDEMNLNC FILMFDLLLK QMELQDDGIT MGLEHSLSKD IISIINNVFQ 
841:	APWGGSHTCQ KDEKAIECNL CQSSILCYQL ACELLERLAP KEESRLVEPT DSLEDSLLSS 
901:	RPEFIIGPEG EEEENPASKH GENPGNCTEP VEHAAVKNDT ERKFCYQQLP VTLRLIYTIF 
961:	QEMAKFEEPD ILFNMLNCLK ILCLHGECLY IARKDHPQFL AYIQDHMLIA SLWRVVKSEF 
1021:	SQLSSLAVPL LLHALSLPHG ADIFWTIING NFNSKDWKMR FEAVEKVAVI CRFLDIHSVT 
1081:	KNHLLKYSLA HAFCCFLTAV EDVNPAVATR AGLLLDTIKR PALQGLCLCL DFQFDTVVKD 
1141:	RPTILSKLLL LHFLKQDIPA LSWEFFVNRF ETLSLEAQLH LDCNKEFPFP TTITAVRTNV 
1201:	ANLSDAALWK IKRARFARNR QKSVRSLRDS VKGPVESKRA LSLPETLTSK IRQQSPENDN 
1261:	TIKDLLPEDA GIDHQTVHQL ITVLMKFMAK DESSAESDIS SAKAFNTVKR HLYVLLGYDQ 
1321:	QEGCFMIAPQ KMRLSTCFNA FIAGIAQVMD YNINLGKHLL PLVVQVLKYC SCPQLRHYFQ 
1381:	QPPRCSLWSL KPHIRQMWLK ALLVILYKYP YRDCDISKIL LHLIHITVNT LNAQYHSCKP 
1441:	HATAGPLYSD NSNISRYSEK EKGEIELAEY RETGALQDSL LHCVREESIP KKKLRSFKQK 
1501:	SLDIGNADSL LFTLDEHRRK SCIDRCDIEK PPTQAAYIAQ RPNDPGRSRQ NSATRPDNSE 
1561:	IPENPAMEGF PDARRPVIPE VRLNCMETFE VKVDSPVKPA PKEDLDLIDL SSDSTSGPEK 
1621:	HSILSTSDSD SLVFEPLPPL RIVESDEEEE TMNQGDDGPS GKNAASSPSV PSHPSVLSLS 
1681:	TAPLVQVSVE DCSKDFSSKD SGNNQSAGNT DSALITLEDP MDAEGSSKPE ELPEFSCGSP 
1741:	LTLKQKRDLL QKSFALPEMS LDDHPDPGTE GEKPGELMPS SGAKTVLLKV PEDAENPTES 
1801:	EKPDTSAESD TEQNPERKVE EDGAEESEFK IQIVPRQRKQ RKIAVSAIQR EYLDISFNIL 
1861:	DKLGEQKDPD PSTKGLSTLE MPRESSSAPT LDAGVPETSS HSSISTQYRQ MKRGSLGVLT 
1921:	MSQLMKRQLE HQSSAPHNIS NWDTEQIQPG KRQCNVPTCL NPDLEGQPLR MRGATKSSLL 
1981:	SAPSIVSMFV PAPEEFTDEQ PTVMTDKCHD CGAILEEYDE ETLGLAIVVL STFIHLSPDL 
2041:	AAPLLLDIMQ SVGRLASSTT FSNQAESMMV PGNAAGVAKQ FLRCIFHQLA PNGIFPQLFQ 
2101:	STIKDGTFLR TLASSLMDFN ELSSIAALSQ LLEGLNNKKN LPAGGAMIRC LENIATFMEA 
2161:	LPMDSPSSLW TTISNQFQTF FAKLPCVLPL KCSLDSSLRI MICLLKIPST NATRSLLEPF 
2221:	SKLLSFVIQN AVFTLAYLVE LCGLCYRAFT KERDKFYLSR SVVLELLQAL KLKSPLPDTN 
2281:	LLLLVQFICA DAGTKLAEST ILSKQMIASV PGCGTAAMEC VRQYINEVLD FMADMHTLTK 
2341:	LKSHMKTCSQ PLHEDTFGGH LKVGLAQIAA MDISRGNHRD NKAVIRYLPW LYHPPSAMQQ 
2401:	GPKEFIECVS HIRLLSWLLL GSLTHNAVCP NASSPCLPIP LDAGSHVADH LIVILIGFPE 
2461:	QSKTSVLHMC SLFHAFIFAQ LWTVYCEQSA VATNLQNQNE FSFTAILTAL EFWSRVTPSI 
2521:	LQLMAHNKVM VEMVCLHVIS LMEALQECNS TIFVKLIPMW LPMIQSNIKH LSAGLQLRLQ 
2581:	AIQNHVNHHS LRTLPGSGQS SAGLAALRKW LQCTQFKMAQ VEIQSSEAAS QFYPL