4.A.3.2.14
PTS transporter, IICAB2cel. IIC has 487 aas and 10 predicted TMSs. This system transports cellobiose, cellotriose, and cellotetraose, and possible higher MW oligosaccharides in this series. It has its own IIB protein but uses the IIA protein of the Cel1 system (TC# 4.A.3.2.13) (Combret et al. 2025). In addition to IIC, IIA and IIB, three additional proteins seem to be required for function, although what these biochemical functions are is not known. These proteins are designated CelG (73 aas), CelH (67 aas) and CelI (137 aas) and are the last three proteins included in this system in TCDB (see Combret et al. 2025 for more details). UniProt acc #s for CelB2, CelC2, CelG, CelH and CelI of E. faecalis are Q836U5, Q836U4, Q836U3, Q836U2, and Q836U1, respectively.
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| Accession Number: | WP_002364646 |
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| Protein Name: | WP_002364646.1 MULTISPECIES: PTS sugar transporter subunit IIC [Enterococcus] |
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| Length: | 488 |
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| Molecular Weight: | |
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| Species: | Enterococcus [1350] |
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| Number of TMSs: | 11 |
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| Substrate |
cellobiose, cellooligosaccharide |
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1: MNGLMAWMEK YILPTAAKIG AQKHLVALRD AFIGTLPATM AGSVAVMINA IIRDLPQEFV
61: STYAASLEAD KGIFAVLNVI IGINGFVWNG TLAIAGLIFA FSWGYNLAKA YNVNELAGGI
121: VSLATLISGV AFAPNNTAEL AVKVPEKIAN AINGAEIGAS IANNQLTVNP WGWLNLNHLN
181: GNAFFTVMIM GALSTIIFCK LMQADLTIKM PDSVPPAVSK AFAAILPATI ALYVVAIINF
241: TVSKLSGGQL LIDLIQKYIA EPFLGLSQGL GAVLIVTVFV QIFWFFGIHG PNVLAPVLEG
301: IWGQAQLINI DIFQKGYEGK TGTAAVLAAI DDGKAYMWVR GSFDAFAWFG GSGGTIVLII
361: AILLFSKRAD YLTVGKLSLG PGIFNINEPI MFGLPVVLNP IMFIPFVIAP LVATTIGWVA
421: TYLGLVAPVS QQVAWVTPPL LLSFLATGAD WRAPIVALVC MVVTFLIWTP FVIAANKMDP
481: ALGESEQ