1.A.1.10.13
Voltage-sensitive Na+ channel of 2821 or 2844 aas (see Uniprot Q9W0Y8) aas and 24 TMSs (Cohen et al. 2009). Pyrethroid, an insecticide,
binds to insect Na+ channels at two sites called pyrethroid,receptors, PyR1 (initial) and PyR2, located in the domain interfaces II/III and I/II, respectively, and binding residues have been identified (Du et al. 2015). It's homologue in honeybees, CaV4, has distinct permeation, inactivation, and pharmacology from homologous NaV channels (Bertaud et al. 2024). Specifically, honeybee CaV4 has distinct permeation, being specific for Ca2+, and exhibits inactivation, and pharmacology differing from homologous NaV channels (Bertaud et al. 2024).
|
| Accession Number: | Q9W0Y8 |
|---|
| Protein Name: | Sodium channel protein 60E |
|---|
| Length: | 2821 |
|---|
| Molecular Weight: | 318625.00 |
|---|
| Species: | Drosophila melanogaster (Fruit fly) [7227] |
|---|
| Number of TMSs: | 21 |
|---|
| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
sodium(1+) |
|---|
1: MSDDQATFND EKAVAKHQVV AYTQRSQVKH ENRHIQLVRE YGFHPRTKAS VEDGDVLPRK
61: FEPFPEHMYG KPLEEIDTFI YEETFCVVSK RFRKNYIHRF TGTKSLFLFY PWSPARRVCV
121: YIATNQFFDY CVMATILFNC IFLAMTETVE EAEYIFLAIY SIEMVIKIIA KGFLLNKYTY
181: LRNPWNWLDF VVITSGYATI GMEVGNLAGL RTFRVLRALK TVSIMPGLKT IINALLHSFR
241: QLAEVMTLTI FCLMVFALFA LQVYMGELRN KCVRQVPTDW TNVSHTDWQI WVNDTDNWLY
301: DEDELPVLCG NLTGARHCPF EYVCLCVGEN PNHGYTNFDN FMWSMLTTFQ LITLDYWENV
361: YNMVLATCGP MSVSFFTVVV FFGSFYLINL MLAVVALSYE EEAEITNEER KKDLLDHRDD
421: STFSFDPSVL NVKKLNKNNK KKIDSRKGVL LASYSKKKTR RKKTKGGKEG GTNGNGNGSN
481: GDDNKSHSAT PSPGPSPRHS ATERPSALTM QAQKQYQQME QQHKLAKSGS GGSNNPMAPT
541: PKGRISFQDS GMGVKNPNML YPSDYKGQLI ANSGQPSSNS SGVNRESSQD DSGVVDDHEE
601: QDTTNDMGHV STVELALSPR EVRLIKCNGN IARIKNHNVY ALHQEFSSEV VVIDDLPDRN
661: CDRCVHWCTD YESWLQFQNC LYKVVRDPLF ELAITLCIVL NTAFLAMEHH GMSESFRNAL
721: DVGNKVFTSI FTFECIVKLM ALSKDFFLCG WNIFDLLIVT ASLLDIIFEL VDGLSVLRGL
781: RLLRVLKLAQ SWTTMKVLLS IIISTIGALG NLTLILVIVI YIFAVIGMQL FSKDYTPEKF
841: DPDPVPRWNF NDFFHSFMMI FRILCGEWIE PLWDCMRAEE EQGASTCFAI FLPTLVMGNF
901: MEVGEESKLA RSIERVRDLI RKKRQERKDR KERKFAEKFQ QIVLDAQQAH AQTLSHQAAV
961: GLERGDKPGV LAETKFHRLS YQESMNRPVS GSDFGFQIPL HDGLHTIVDG LEYDDTGDLP
1021: EQIQLQAHPL PPTSDSMPPT YESAMMATTG GSFSSVNGNG TCQNLTPFVQ AERRLQHQIS
1081: SGVSTQQYDS REEATYTESI ELLGQYNSTD TDPYANDQRS GCGSFNRGDS LQDNSSRRYG
1141: SEEHDEAFLK YQKSLLTRSP SYRKSLDRLS QSSGQSQRSL LKSEEAEMRR HSSGQSLNSM
1201: SIEQDELLSQ QGNLREELLN CDQKELFQFL QEEEELQKGT KLRRISNVMR SRRPSSQMGQ
1261: PENETMVEHS EFDNIIQSFE KELEEIKRST TSLERKLSNL SEPSPAADEA TKAIMEHIAI
1321: ITGASERSAA DEVVLPLNPY DSYDLSSVPR RSQSVSAAAQ RQSVKLKRRS LEKQRKIDED
1381: FSISNEIRKI CDQIHAPFVA MEAMAVAATS ASQAQPNQSP FLRRKVDPFT VQFDRFKRLS
1441: LIERVEEVPE EEKPISTLRI ESEKMPRKFL HGPDQLRLDS LSLKSTNSYE NLLIQKQKLG
1501: MATPPAVPAT PPTSLKSSIE PPTLAQISSL KTTPPLAALT EHQQHFHATS IQAAPTPAHT
1561: HAHSQAHAHS MAGQRRRMEH PQSTLDKAAS FQSARTESHS SGAADASSAL ALAMAQKTEQ
1621: SQSTAPDATQ KPSAFTRLTE KPWHCLVSYV DDLTVGGRRN SQGAYNDPMT FPSYGATKAA
1681: KVPDDCFPQK CYDHFYFRCP WFMSCMDTQS AKHWTRVRTA VLTVVDTPAF EWFVLVLIFA
1741: SSITLCFEDI NLDKNKTLKR VLYWINFSFC LIFVVEMILK WLALGFSKYF TSFWTILDFI
1801: IVFVSVFSLL IEENENLKVL RSLRTLRALR PLRAISRWQG MRIVVNALMY AIPSIFNVLL
1861: VCLVFWLIFS IMGVQFFGGK FFKCVNEMGE LLPITEVNDK WDCIEQNYTW INSKITFDHV
1921: GMGYLALLQV ATFEGWMEVM ADAVDARGVD LQPQREANLY AYIYFVIFIV CGSFFTLNLF
1981: IGVIIDNFNM LKKKYEGGVL EMFLTESQKH YYTAMKKLGR KKPQKVIKRP INHFLAMFYD
2041: LSNSRRFEIA IFVLIFLNML TMGIEHYDQP HAVFFILEVS NAFFTTVFGL EAIVKIVGLR
2101: YHYFTVPWNV FDFLLVLASI FGILMEDIMI DLPISPTLLR VVRVFRIGRI LRLIKAAKGI
2161: RKLLFALVVS LPALFNIGAL LGLITFIYAI LGMSLFGNVK LQGALDDMVN FQTFGRSMQL
2221: LFRLMTSAGW NDVLESLMIQ PPDCDPFIHG HTNGNCGHPL LAITYFTSFI IISYMIVINM
2281: YIAIILENFN QAHQEEEIGI VEDDLEMFYI RWSKYDPHAT QFIHFSQLSD FIASLDPPLG
2341: ISKPNNVALV SFNLPISKGN KIHCLDILHA LVKHVLGHVE ETDNFKQLQE QMDVKFKKQF
2401: PTRKELEIVS STRIWKRQEK AAKTIQTGWK EYLRRKREKE RSNSGDSATQ TSSPGGWQSK
2461: LSALNFFHLQ VSRRGTACSS RASSRKSSRA SDASDLSELA GPWLNLPLML VSGADEVVKD
2521: IKQQNDELGK RGSIFVEAPR ASRRRSFYNF FLRHQDAVDD SLTSPSVHRK TAMNNTTNTT
2581: SNSASTSGTA SSTATAPATG CGPAATSASD SDRHQAVGGG SAPSRKRASS FIRKKPPLER
2641: GLSAQSALRV NKNAFVSEAS APEVIVTRPS PEQQTHPHSL SLRPDNATLV HVLVHRESEE
2701: YKEEDESSPS VSGNGNGFGV GLDMLSKQPP PQIRITTGSV ESSMDTCAMP TVQIMVDSPK
2761: DPPRGDFSSA PIDDVGAPID VNVQGDTSQV FYDYNPEKAT DDQGNGQDET AQFESLPDRQ
2821: R