1.A.1.10.15
The sodium channel of 1989 aas and 24 TMSs. 80% identical to the characterized channel of the crayfish (Astacus leptodactylus (Turkish narrow-clawed crayfish) (Pontastacus leptodactylus)) in which functional regions responsible for the selectivity filter, inactivation gate,
voltage sensor, and phosphorylation have been identified (Coskun and Purali 2016).
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| Accession Number: | A1E023 |
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| Protein Name: | Sodium channel protein |
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| Length: | 1989 |
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| Molecular Weight: | 225742.00 |
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| Species: | Cancer borealis (Jonah crab) [39395] |
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| Number of TMSs: | 21 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sodium(1+) |
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1: MPLPNRLQSS FPDDLVGVPL EDIDQFYHNR KTTVVISKGR DIFRFSATDA MWILSPFNPV
61: RRTAMFILIH PLFNFFIICT ILANCVLMIM PTNETIESSE VLFTAIYTFE SGVKVMARGF
121: ILESFTYLRD AWNWLDFTVI SLAYVTMGID LGNLAALRTF RVLRALKTVA IVPGLKTIVG
181: AVIESVKNLR DVIILTVFSL SVFALLGLQI YMGVLTQKCI RKFDFTKENW TLDDVENFYM
241: NQSNWLKDEG VQDSPLCGNS SGAGTCPHNY ICRQGYGPSP NYGYTNFDSF GWSFLSAFRL
301: MTQDYWENLY QLVLRSAGPW HIIFFVVIIF LGSYYLVNLI LAIVAMSYDQ LQKKAEEEEE
361: AALAEEEELK AREEKELADT QRALDLAAGL EDGGSMINSP SVYSGDTYEN YNSTDQGGDD
421: TMKDASIRSE EQDSRGRHNG KRKASISLPG SPYNPRRGSR SSHQCTWRTS NGRRFGDRKP
481: LVLSTYMDAM EHLPYADDSN AVTPMSEENG AIIVPVYTTL GSRHNSYTSH TSRISYTSHG
541: DLLNGKPPTT KASKLLNRSP RNMNTSLPPE LDNNMLQMLP LRPEGEAMRR KEDEVIDNII
601: REIFGPDITL EYIDKDASAQ ATPLARSKEN VVEDSDDMLA LKLKNPDANP FIDPIQKQTV
661: VDMRDVRVLQ DIIEQAAVNA GRMSRASDHG VSIYYFSAEE EEESFKEKLK KKLLEYLLKA
721: IDIFCVWDCC SYWNKFAKLV ELLVFDPFVE LFITLCIVVN TLFMAMDHYG MNCSFDHFLK
781: MGNYFFTATF SIECFLKIIA MSPKYYLQEG WNIFDFIIVF LSLLELGLAN VSGLSVLRSF
841: RLLRVFKLAK SWPTLNLLIS IMGKTVGALG NLTFVLCIII FIFAVMGMQL FGKNYTEKVM
901: KFPPNPDGQL PRWNFTDFMH SFMIVFRVLC GEWIESMWDC MLVCGYSCIP FFMATVIIGN
961: LVVLNLFLAL LLSSFGASNL SAPPSDGDTN KLSEAFERIA RFKAWVKRTV FNVLKHVRAK
1021: LTNQISDQTP DGRDLEGEDI LMDGQTGNKK LPKDHTQVDI PMDGFDLPDG KMKNNTVINN
1081: KYIGNSVSLD NRDVAIIEND YGNNKKAKRL EEDALSNNSL GSHRHHKLKS DSGSHKGSTE
1141: TVDDGEEKRD ASKEDFDDDH GGSGDEGELE EEEGEDVGPV VDTGSNAALD YPSDCFKEGC
1201: YTRWPFCAGD PESPFWQGWG HLRLKTYQLI ENKYFETAVI TMILLSSLAL AAEDVNLKGR
1261: PALQDILYYM DRIFTVIFFI EMLIKWVALG FSKYFTNAWC WLDFLIVMVS LINLVATLAG
1321: GGKIQAFKTM RTLRALRPLR ALSRMQGMRV VVNALVGAIP SIVNVLLVCL IFWLIFAIMG
1381: VQLFNGRYHK CIDAEGLKLN AEIVPDRLMC LYMNYSWVNS EVHFDHVGMA YLALFQVATW
1441: KGWIQIMNDA IDSTQLEKQP MREVNINMYM YFVFFIIFGS FFTLNLFIGV IIDNFNEQKK
1501: KAGGSLEMFM TDDQKKYYNA MKKMGGKKPL KAIPRPQFRP QAVVFEIVTS KKFDMIIMIF
1561: IGMNMLTMTM DHYQMTETWK MGLNYLNLIF ICIFTSECVL KVFALRWHYF KEPWNLYDFV
1621: VVIMSILGMV LKDIIEKYFV SPTLLRVVRV AKVGRVLRLV KGAKGIRTLL FALAMSLPAL
1681: FNICLLLFLV MYISAIYGMS FFMNVKHTGG LDSVYNFETF FQSFILLFQM MTSAGWDGVL
1741: SGIVNEKNCK PPNPEVGDPG DCGNQAIGIA YLLGYLVISF LIVINMYIAV ILENYSQATE
1801: DVEEGLTDDD YDMYYEIWQQ FDPKGTQYIL FAQVSDFLDV LEAPLQIHKP NKYKIVSMDI
1861: TICKGDLVFC VDVLDALTKD FFARKGNPVE DSADMGDVGP PQDRPGYEPV SSTLWRQREE
1921: YCARLIQQAW RRHRQHKDQS SLSGGESQEE LKQADTAVLV ESDGYVTKNG HKVVIHSRSP
1981: SLTSRSTDV