1.A.1.10.16
The voltage-gated sodium channel of 2147 aas and 24 TMSs. Several mutations in the structural gene give rise to pyrethroid resistance (kdr) (Saavedra-Rodriguez et al. 2007). A novel strategy for screening mutations in
the voltage-gated sodium channel gene of Aedes albopictus based on
multiplex PCR-mass spectrometry minisequencing technology, has appeared (Mu et al. 2023).
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| Accession Number: | C3RTM3 |
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| Protein Name: | Sodium channel protein |
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| Length: | 2147 |
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| Molecular Weight: | 240913.00 |
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| Species: | Aedes aegypti (Yellowfever mosquito) [7159] |
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| Number of TMSs: | 22 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sodium(1+) |
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1: MTEDSDSISE EERSLFRPFT RESLAAIERR IADAEAKQRE LEKKRAEGET GFGRKKKKKE
61: IRYDDEDEDE GPQPDSTLEQ GVPIPVRMQG SFPPELASTP LEDIDSYYAN QRTFVVVSKG
121: KDIFRFSATN ALYVLDPFNP IRRVAIYILV HPLFSFFIIT TILTNCILMI MPSTPTVEST
181: EVIFTGIYTF ESAVKVMARG FILQPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT
241: FRVLRALKTV AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC
301: IREFPMDGSW GNLSDENWER FNNNDSNWYF SETGDTPLCG NSSGAGQCEE GYICLQGYGD
361: NPNYGYTSFD TFGWAFLSAF RLMTQDYWEN LYQLVLRSAG PWHMLFFIVI IFLGSFYLVN
421: LILAIVAMSY DELQKRAEEE EAAEEEALRE AEEAAAAKAA KLEAQAAAAA AAANPEIAKS
481: PSDFSCHSYE LFVNQEKGND DNNKEKMSIR SEGLESVSEI TRTTAPTATA AGTAKARKVS
541: AGVAAFQKAS LSLPGSPFNL RRGSRGSHQF TIRNGRGRFV GVPGSDRKPL VLSTYLDAQE
601: HLPYADDSNA VTPMSEENGA IIVPVYYANL GSRHSSYTSH QSRISYTSHG DLLGGMTKES
661: RLRNRSARNT NHSIVPPPNM SGPNMSYVDS NHKGQRDFDM SQDCTDEAGK IKHNDNPFIE
721: PSQTQTVVDM KDVMVLNDII EQAAGRHSRA SDHGVSVYYF PTEDDDEDGP TFKDKALEFT
781: MRMIDVFCVW DCCWVWLKFQ EWVAFIVFDP FVELFITLCI VVNTLFMALD HHDMDPDMER
841: ALKSGNYFFT ATFAIEATMK LIAMSPKYYF QEGWNIFDFI IVALSLLELG LEGVQGLSVL
901: RSFRLLRVFK LAKSWPTLNL LISIMGRTMG ALGNLTFVLC IIIFIFAVMG MQLFGKNYID
961: NVDRFPDKDL PRWNFTDFMH SFMIVFRVLC GEWIESMWDC MLVGDVSCIP FFLATVVIGN
1021: LVGLNLFLAL LLSNFGSSSL SAPTADNETN KIAEAFNRIS RFSNWIKSNI ANALKFVKNK
1081: LTSQIASVQP AGEQHNHLSW IWNEGKGVCP CISAEHGENE LELTPDDILA DGLLKKGVKE
1141: HNQLEVAIGD GMEFTIHGDL KNKGKKNKQL MNNSKVIGNS ISNHQDNKLE HELNHRGMSL
1201: QDDDTASIKS YGSHKNRPFK DESHKGSAET MEGEEKRDVS KEDLGIDEEL DDECDGEEGP
1261: LDGELIIHAD EDEVIEDSPA DCCPDNCYKK FPVLAGDDDA PFWQGWANLR LKTFQLIENK
1321: YFETAVITMI LLSSLALALE DVHLPHRPIL QDVLYYMDRI FTVIFFLEML IKWLALGFRV
1381: YFTNAWCWLD FIIVMVSLIN FVASLCGAGG IQAFKTMRTL RALRPLRAMS RMQGMRVVVN
1441: ALVQAIPSIF NVLLVCLIFW LIFAIMGVQL FAGKYFKCVD KNKTTLSHEI IPDVNACVAE
1501: NYTWENSPMN FDHVGKAYLC LFQVATFKGW IQIMNDAIDS REVGKQPIRE TNIYMYLYFV
1561: FFIIFGSFFT LNLFIGVIID NFNEQKKKAG GSLEMFMTED QKKYYNAMKK MGSKKPLKAI
1621: PRPRWRPQAI VFEIVTNKKF DMIIMLFIGF NMLTMTLDHY KQTDTFSAVL DYLNMIFICI
1681: FSSECLMKIF ALRYHYFIEP WNLFDFVVVI LSILGLVLSD LIEKYFVSPT LLRVVRVAKV
1741: GRVLRLVKGA KGIRTLLFAL AMSLPALFNI CLLLFLVMFI FAIFGMSFFM HVKYKSGLDD
1801: VYNFKTFGQS MILLFQMSTS AGWDGVLDGI INEDECLPPD NDKGYPGNCG SATIGITYLL
1861: AYLVISFLIV INMYIAVILE NYSQATEDVQ EGLTDDDYDM YYEIWQQFDP DGTQYIRYDQ
1921: LSDFLDVLEP PLQIHKPNKY KIISMDIPIC RGDMMFCVDI LDALTKDFFA RKGNPIEETA
1981: ELGEVQARPD EVGYEPVSST LWRQREEYCA RVIQHAWRKH KERQAGGGGG DDTDADACDN
2041: DDGDDGGGGA GDGGSAGGGG VTSPGVGSGS IVGGGTTPGS GGGGSQANLG IVVEHNLSPK
2101: ESPDGNNDPQ GRQTAVLVES DGFVTKNGHR VVIHSRSPSI TSRSADV