1.A.1.10.18
Sodium channel protein, α-subunit, FPC1, of 2050 aas and 24 TMSs. The 3-d structure has been solved by cryoEM to 3.8 Å resolution (Shen et al. 2017). One residue at the corresponding selectivity filter (SF) locus in each repeat, Asp/Glu/Lys/Ala (DEKA), determines Na+ selectivity. The S1 to S4 segments in each repeat form a
voltage-sensing domain (VSD), wherein S4 carries repetitively occurring
positive residues essential for voltage sensing. There are seven extracellular glycosylation sites (Shen et al. 2017).
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| Accession Number: | D0E0C1 |
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| Protein Name: | Sodium channel protein |
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| Length: | 2050 |
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| Molecular Weight: | 232057.00 |
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| Species: | Periplaneta americana (American cockroach) [6978] |
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| Number of TMSs: | 24 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sodium(1+) |
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1: MSDDSSSISE EERSLFRPFT RESLAAIEAR IAEEYAKRKE LEKKRAEGEG DSGRKRKKKE
61: VRYDDEDEDE GPQPDATLEQ GAPIPVRMQG LFPPELASTP LEDIDPFYQN QRTFVVVSKG
121: KDIFRFSATE AMWILDPFNP IRRVAIYILV HPLFSLFIIT TILTNCIFMI MPTTPTIEST
181: EVIFTGIYTF ESAVKVMARG FILQPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT
241: FRVLRALKTV AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC
301: VKNFPSDGSW GNLTDENWFS FCSNKSHWYI PDDTIEYPLC GNSSGAGTCP PGYTCLQGFG
361: DNPNYGYTSF DTFGWAFLSA FRLMTQDYWE NLYQLVLRSA GPWHMLFFIV IIFLGSFYLV
421: SLILAIVAMS YDELQKKAEE EEAAEEEALR EAEEAARAKE AKRARQADKE AAHAAGLAQA
481: AAEVVKSPSG SSCLSYELFV GQKGNADNNK EKMSIRSEEG DSISEHRRIV GANGTAGVRK
541: VSAASLSLPG SPFNLRRGSR GSHQFPIRNG RGRFVGPPGG DRKPLVLSTY LDAQEHLPYA
601: DDSNAVTPMS EENGAIVVPV YYANLGSRHS SYTSHASRIS YTSHGDLLGA GGKPRTKESQ
661: LRTRSGRNNP SQLPNSTPYM SDDHKYMDAS VDSDDGAVKA KHSDNPFIEQ MQQTTIVDMN
721: DVMVLNDIIE QAAGRQSRAS EQGDEDDEGP TVKEKVLAIC LRGIDIFCVW DCCWLWLKFQ
781: EYVALLVFDP FVELFITLCI VVNMLFMALD HYDMNKDMEK ALKSGNYFFT ATFAIEATLK
841: LIAMSPKYYF QEGWNIFDFI IVALSLLELG LEGVQGLSVL RSFRLLRVFK LAKSWPTLNL
901: LISIMGRTVG ALGNLTFVLC IIIFIFAVMG MQLFGKNYFD NVERFPDGDT PRWNFADFMH
961: SFMIVFRVLC GEWIESMWDC MLVGDWSCIP FFLATVVIGN LVVLNLFLAL LLSNFGSSNL
1021: SAPTADNETN KIAEAFDRFS RLFNWIKRSA LSVAKMLRAK LTNQISDQTP GEGPSSSWKE
1081: DAHDRDTDLD LTADEIIADG MVYRDKKSPK DQTQLEVAIG DGMEFTIHGD LKNKLKEDKL
1141: LMNNTKVIGN SFQGNHKDNR IENDYLHNRQ DEDTLSTRSY GSHKNRPFKD ESHKGSAETM
1201: DGEGKKDASK EDLEQEGNAE EDGEGEEGHL EEDMALDGGT EDVMMSEYPA DCCPEKCYRR
1261: FPFLAGDEDS PFWQGWGNLR LKTFQLIENK YFETAVITMI LLSSLALALE DVHLSYRPIL
1321: QDILYYMDRI FTVIFFIEML IKWLALGFKK YFTNAWCWLD FVIVMVSLIN FVASLVGAGG
1381: IQAFKTMRTL RALRPLRAMS RMQGMRVVVN ALVQAIPSIF NVLLVCLIFW LIFAIMGVQL
1441: FAGKYHKCVD GNSTTLSHEI IPDRNACIAE NYTWENSPMN FDHVGKAYLC LFQVATFKGW
1501: IQIMNDAIDS RDLFKQPIRE TNIYMYLYFV FFIIFGSFFT LNLFIGVIID NFNEQKKKAG
1561: GSLEMFMTED QKKYYNAMKK MGSKKPLKAI PRPKWKPQAI VFEICTNKKF DMIIMLFIGF
1621: NMLTMTLDHY QQSQQFSDVL DYLNMIFIVI FSSECLMKIF ALRYHYFKEP WNLFDFVVVI
1681: LSILGLVLSD IIEKYFVSPT LLRVVRVAKV GRVLRLVKGA KGIRTLLFAL AMSLPALFNI
1741: CLLLFLVMFI FAIFGMSFFM HVRDKGGLDD VYNFKTFGQS MILLFQMSTS AGWDGVLDGI
1801: MNEDDCRKPD NELGYPGNCG SATIGIAFLL SYLVISFLIV INMYIAVILE NYSQATEDVQ
1861: EGLTDDDYDM YYEIWQQFDP DGTQYIRYDQ LSEFLDVLEP PLQIHKPNKY KIVSMDIPIC
1921: KGDLMFCVDI LDALTKDFFA RKGNAIDESG ELGEVQARPD EVGYEPVSST LWRQREEYCA
1981: RLIQNAWRKH KQQRQGGPGE DSDDAGDDAD LHDRHQTAVL VESDGFVTKN GHRVVIHSRS
2041: PSVTSRSTDV