1.A.1.10.22
The Na+-activated Na+ channel (Nax; also called SCN7A; of 1737 aas and ~24 TMSs) and salt-inducible kinase (SIK, see TC# 8.A.104.1.14) are stimulated by increases in local Na+ concentration, affecting the Na+,K+-ATPase activity (see TC# 3.A.3.1.1). It mediates the voltage-dependent sodium ion permeability of excitable
membranes. Assuming opened or closed conformations in response to the
voltage difference across the membrane, the protein forms a
sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient (Gonsalez et al. 2023). Rare SCG genetic variants may contribute to the development of painful neuropathy (Almomani et al. 2023).
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| Accession Number: | 7TJ9_A |
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| Protein Name: | A Chain A, Sodium channel protein type 7 subunit alpha |
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| Length: | 1738 |
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| Molecular Weight: | |
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| Species: | Homo sapiens [9606] |
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| Number of TMSs: | 22 |
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| Substrate |
sodium(1+) |
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1: MWSHPQFEKG GGSGGGSGGS AWSHPQFEKF FSFFDYKDDD DKGGSGGDYK DDDDKMLASP
61: EPKGLVPFTK ESFELIKQHI AKTHNEDHEE EDLKPTPDLE VGKKLPFIYG NLSQGMVSEP
121: LEDVDPYYYK KKNTFIVLNK NRTIFRFNAA SILCTLSPFN CIRRTTIKVL VHPFFQLFIL
181: ISVLIDCVFM SLTNLPKWRP VLENTLLGIY TFEILVKLFA RGVWAGSFSF LGDPWNWLDF
241: SVTVFEVIIR YSPLDFIPTL QTARTLRILK IIPLNQGLKS LVGVLIHCLK QLIGVIILTL
301: FFLSIFSLIG MGLFMGNLKH KCFRWPQENE NETLHNRTGN PYYIRETENF YYLEGERYAL
361: LCGNRTDAGQ CPEGYVCVKA GINPDQGFTN FDSFGWALFA LFRLMAQDYP EVLYHQILYA
421: SGKVYMIFFV VVSFLFSFYM ASLFLGILAM AYEEEKQRVG EISKKIEPKF QQTGKELQEG
481: NETDEAKTIQ IEMKKRSPIS TDTSLDVLED ATLRHKEELE KSKKICPLYW YKFAKTFLIW
541: NCSPCWLKLK EFVHRIIMAP FTDLFLIICI ILNVCFLTLE HYPMSKQTNT LLNIGNLVFI
601: GIFTAEMIFK IIAMHPYGYF QVGWNIFDSM IVFHGLIELC LANVAGMALL RLFRMLRIFK
661: LGKYWPTFQI LMWSLSNSWV ALKDLVLLLF TFIFFSAAFG MKLFGKNYEE FVCHIDKDCQ
721: LPRWHMHDFF HSFLNVFRIL CGEWVETLWD CMEVAGQSWC IPFYLMVILI GNLLVLYLFL
781: ALVSSFSSCK DVTAEENNEA KNLQLAVARI KKGINYVLLK ILCKTQNVPK DTMDHVNEVY
841: VKEDISDHTL SELSNTQDFL KDKEKSSGTE KNATENESQS LIPSPSVSET VPIASGESDI
901: ENLDNKEIQS KSGDGGSKEK IKQSSSSECS TVDIAISEEE EMFYGGERSK HLKNGCRRGS
961: SLGQISGASK KGKIWQNIRK TCCKIVENNW FKCFIGLVTL LSTGTLAFED IYMDQRKTIK
1021: ILLEYADMIF TYIFILEMLL KWMAYGFKAY FSNGWYRLDF VVVIVFCLSL IGKTREELKP
1081: LISMKFLRPL RVLSQFERMK VVVRALIKTT LPTLNVFLVC LMIWLIFSIM GVDLFAGRFY
1141: ECIDPTSGER FPSSEVMNKS RCESLLFNES MLWENAKMNF DNVGNGFLSL LQVATFNGWI
1201: TIMNSAIDSV AVNIQPHFEV NIYMYCYFIN FIIFGVFLPL SMLITVIIDN FNKHKIKLGG
1261: SNIFITVKQR KQYRRLKKLM YEDSQRPVPR PLNKLQGFIF DVVTSQAFNV IVMVLICFQA
1321: IAMMIDTDVQ SLQMSIALYW INSIFVMLYT MECILKLIAF RCFYFTIAWN IFDFMVVIFS
1381: ITGLCLPMTV GSYLVPPSLV QLILLSRIIH MLRLGKGPKV FHNLMLPLML SLPALLNIIL
1441: LIFLVMFIYA VFGMYNFAYV KKEAGINDVS NFETFGNSML CLFQVAIFAG WDGMLDAIFN
1501: SKWSDCDPDK INPGTQVRGD CGNPSVGIFY FVSYILISWL IIVNMYIVVV MEFLNIASKK
1561: KNKTLSEDDF RKFFQVWKRF DPDRTQYIDS SKLSDFAAAL DPPLFMAKPN KGQLIALDLP
1621: MAVGDRIHCL DILLAFTKRV MGQDVRMEKV VSEIESGFLL ANPFKITCEP ITTTLKRKQE
1681: AVSATIIQRA YKNYRLRRND KNTSDIHMID GDRDVHATKE GAYFDKAKEK SPIQSQI