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1.A.1.11.2
Muscle plasmalemma, voltage-gated, L-type dihydropyridine receptor Ca2+ channel, α-1 subunit (DHPR) (Ba2+ > Ca2+), Cav1.1, CACNA1S,CACH1 CDCN1, CACNL1A3 of 1873 aas in the human orthologue.  Distinc voltage sensor domains control voltage sensitivity and kinetics of current activation (Tuluc et al. 2016). Rapid changes in the transmembrane potential are detected by the voltage-gated Ca2+ channel, dihydropyridine receptor (DHPR), embedded in the sarcolemma. DHPR transmits the contractile signal to another Ca2+ channel, the ryanodine receptor (RyR1), embedded in the membrane of the sarcoplasmic reticulum (SR), which releases a large amounts of Ca2+ from the SR that initiate muscle contraction (Shishmarev 2020).

Accession Number:P07293
Protein Name:CACNA1S aka CACNL1A3 aka CACH1
Length:1873
Molecular Weight:212029.00
Species:Oryctolagus cuniculus (Rabbit) [9986]
Number of TMSs:18
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: maNOG17008
RefSeq: NP_001095190.1   
Entrez Gene ID: 100009585   
Pfam: PF08763    PF00520   

Gene Ontology

GO:0005891 C:voltage-gated calcium channel complex
GO:0005245 F:voltage-gated calcium channel activity
GO:0006816 P:calcium ion transport
GO:0055085 P:transmembrane transport

References (10)

[1] “Primary structure of the receptor for calcium channel blockers from skeletal muscle.”  Tanabe T.et.al.   3037387
[2] “Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel.”  Ellis S.B.et.al.   2458626
[3] “Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit.”  Pragnell M.et.al.   7509046
[4] “Identification of a phenylalkylamine binding region within the alpha 1 subunit of skeletal muscle Ca2+ channels.”  Striessnig J.et.al.   2174553
[5] “Identification of 1,4-dihydropyridine binding regions within the alpha 1 subunit of skeletal muscle Ca2+ channels by photoaffinity labeling with diazipine.”  Nakayama H.et.al.   1656465
[6] “Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit.”  Striessnig J.et.al.   1660150
[7] “CAMP-dependent protein kinase rapidly phosphorylates serine-687 of the skeletal muscle receptor for calcium channel blockers.”  Roehrkasten A.et.al.   2844809
[8] “Activation of purified calcium channels by stoichiometric protein phosphorylation.”  Nunoki K.et.al.   2549550
[9] “A structural requirement for activation of skeletal ryanodine receptors by peptides of the dihydropyridine receptor II-III loop.”  Casarotto M.G.et.al.   10766780
[10] “Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha1 interaction domain.”  Opatowsky Y.et.al.   15134636
Structure:
1DU1   1T3L   3JBR   5gjv   1JZP   5GJW   6BYO   6JP5   6JP8   6JPA   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MEPSSPQDEG LRKKQPKKPL PEVLPRPPRA LFCLTLQNPL RKACISIVEW KPFETIILLT 
61:	IFANCVALAV YLPMPEDDNN SLNLGLEKLE YFFLTVFSIE AAMKIIAYGF LFHQDAYLRS 
121:	GWNVLDFIIV FLGVFTAILE QVNVIQSNTA PMSSKGAGLD VKALRAFRVL RPLRLVSGVP 
181:	SLQVVLNSIF KAMLPLFHIA LLVLFMVIIY AIIGLELFKG KMHKTCYYIG TDIVATVENE 
241:	KPSPCARTGS GRPCTINGSE CRGGWPGPNH GITHFDNFGF SMLTVYQCIT MEGWTDVLYW 
301:	VNDAIGNEWP WIYFVTLILL GSFFILNLVL GVLSGEFTKE REKAKSRGTF QKLREKQQLE 
361:	EDLRGYMSWI TQGEVMDVED LREGKLSLEE GGSDTESLYE IEGLNKIIQF IRHWRQWNRV 
421:	FRWKCHDLVK SRVFYWLVIL IVALNTLSIA SEHHNQPLWL THLQDIANRV LLSLFTIEML 
481:	LKMYGLGLRQ YFMSIFNRFD CFVVCSGILE LLLVESGAMT PLGISVLRCI RLLRLFKITK 
541:	YWTSLSNLVA SLLNSIRSIA SLLLLLFLFI IIFALLGMQL FGGRYDFEDT EVRRSNFDNF 
601:	PQALISVFQV LTGEDWNSVM YNGIMAYGGP SYPGVLVCIY FIILFVCGNY ILLNVFLAIA 
661:	VDNLAEAESL TSAQKAKAEE RKRRKMSRGL PDKTEEEKSV MAKKLEQKPK GEGIPTTAKL 
721:	KVDEFESNVN EVKDPYPSAD FPGDDEEDEP EIPVSPRPRP LAELQLKEKA VPIPEASSFF 
781:	IFSPTNKVRV LCHRIVNATW FTNFILLFIL LSSAALAAED PIRAESVRNQ ILGYFDIAFT 
841:	SVFTVEIVLK MTTYGAFLHK GSFCRNYFNI LDLLVVAVSL ISMGLESSTI SVVKILRVLR 
901:	VLRPLRAINR AKGLKHVVQC VFVAIRTIGN IVLVTTLLQF MFACIGVQLF KGKFFSCNDL 
961:	SKMTEEECRG YYYVYKDGDP TQMELRPRQW IHNDFHFDNV LSAMMSLFTV STFEGWPQLL 
1021:	YRAIDSNEED MGPVYNNRVE MAIFFIIYII LIAFFMMNIF VGFVIVTFQE QGETEYKNCE 
1081:	LDKNQRQCVQ YALKARPLRC YIPKNPYQYQ VWYVVTSSYF EYLMFALIML NTICLGMQHY 
1141:	HQSEEMNHIS DILNVAFTII FTLEMILKLL AFKARGYFGD PWNVFDFLIV IGSIIDVILS 
1201:	EIDTFLASSG GLYCLGGGCG NVDPDESARI SSAFFRLFRV MRLIKLLSRA EGVRTLLWTF 
1261:	IKSFQALPYV ALLIVMLFFI YAVIGMQMFG KIALVDGTQI NRNNNFQTFP QAVLLLFRCA 
1321:	TGEAWQEILL ACSYGKLCDP ESDYAPGEEY TCGTNFAYYY FISFYMLCAF LIINLFVAVI 
1381:	MDNFDYLTRD WSILGPHHLD EFKAIWAEYD PEAKGRIKHL DVVTLLRRIQ PPLGFGKFCP 
1441:	HRVACKRLVG MNMPLNSDGT VTFNATLFAL VRTALKIKTE GNFEQANEEL RAIIKKIWKR 
1501:	TSMKLLDQVI PPIGDDEVTV GKFYATFLIQ EHFRKFMKRQ EEYYGYRPKK DTVQIQAGLR 
1561:	TIEEEAAPEI RRTISGDLTA EEELERAMVE AAMEERIFRR TGGLFGQVDT FLERTNSLPP 
1621:	VMANQRPLQF AEIEMEELES PVFLEDFPQD ARTNPLARAN TNNANANVAY GNSNHSNNQM 
1681:	FSSVHCEREF PGEAETPAAG RGALSHSHRA LGPHSKPCAG KLNGQLVQPG MPINQAPPAP 
1741:	CQQPSTDPPE RGQRRTSLTG SLQDEAPQRR SSEGSTPRRP APATALLIQE ALVRGGLDTL 
1801:	AADAGFVTAT SQALADACQM EPEEVEVAAT ELLKARESVQ GMASVPGSLS RRSSLGSLDQ 
1861:	VQGSQETLIP PRP