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1.A.1.11.29
Voltage-gated calcium channel (VDCC) of 3097 aas and 24 TMSs, Cav7 (Wheeler and Brownlee 2008). The photoreceptor potential in Chlamydomonas triggers the generation of all or no flagellar Ca2+ currents that cause membrane depolarization across the eyespot and flagella (Sanyal et al. 2023). Modulation in membrane potential causes changes in the flagellar waveform, and hence, alters the beating patterns of Chlamydomonas flagella. The eyespot membrane potential is rhodopsin-mediated and is generated by the photoreceptor Ca2+ current or P-current. However, flagellar Ca2+ currents are mediated by unidentified voltage-gated calcium (VGCC or CaV) and potassium channels (VGKC). The voltage-dependent ion channel that associates with ChRs to generate Ca2+ influx across the flagella and its cellular distribution has been identified. Sanyal et al. 2023 presented evidence on Chlamydomonas reinhardtii predicting that CrVGCC4 localizes to the eyespot and flagella and associates with channelrhodopsins. Further in silico interactome analysis of CrVGCCs suggested that they interact with photoreceptor proteins, calcium signaling, and intraflagellar transport components. Expression analysis indicated that these VGCCs and their putative interactors can be perturbed by light stimuli. Thus, VGCCs in general, and VGCC4 in particular, might be involved in the regulation of the phototactic response of Chlamydomonas.

Accession Number:A8IHW3
Protein Name:Voltage-gated Ca2+ channel, alpha subunit
Length:3097
Molecular Weight:328197.00
Species:Chlamydomonas reinhardtii [3055]
Number of TMSs:18
Substrate calcium(2+)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLLAQDPKLQ AAYDSYMASQ LMSSLTEDEM FAATSALGAV QKAYASNNGV RRPTSPSPGV 
61:	EAAGPSGASQ HAGAGDKDVL AAAGVTDARR KRRSSGASCS DMLGEGLGER EHSVARSGHS 
121:	GSARPGSSLA GRQDGEAESG RGTPLQQHPT LPSGKVPLLD SDDFGGPPLP TSAAAVAAAL 
181:	ALVEVKPLAD HIQRDDEHLP PLLGPPPGAP LQPAPPPGAA AAAAAATAGG VGGADVTKDN 
241:	KDGKDGALQQ QDSNNSLGTY DEFGDLGQYS GLRRTCIKLC SNPDFEMVVT AIIFANCVTL 
301:	CLYDPRQPES SGLNKKLFWA ELAFNICFSI EMLLRVVSMG SLLGYIRRPW NQFDSFMVVA 
361:	GYTVFVPGNS SAVNAIRALR ALRPLRTITR FESLRGVIVC FLEAIPLLAS VGGLLIFFVF 
421:	MYAVAAVQLF PKTYHNTCLD PEGVPLNMGE DPDMFGCGGR GHCPANYTCM LLEHQHTVNV 
481:	AGFDNAGLAM LSVWQALTLT GWVFMMYRTI DTYSLYVVIY YLTLVVIGAY FVLNLFLAVL 
541:	KIKFAKAQTL FHNQLALQRG KARRNSIMTF MSRVQTKWTE YSSKRSQASS LNSRLTSAIS 
601:	SKMTSVASAG SPRMSHDGKE AEGEGSKAKR HGSKDKLGSE KGHAGRRRGS ANGSAYEQRS 
661:	ADGFLPGSVE AEGGGDEVGG ARARVEVGSA GGYLAASKGA GSLQASREGT RDGVGSKPEW 
721:	TQLEPLPRPG SPVNAADRGA ARSALAGSRP SSGTPSSRQL SCSSSRVAFM PAPGEPGVRF 
781:	AGGDDEPGNE GDHPSARTGP RGGGGVRFGD EPASEPGGHG SDPTSPHLGA GEYTHRSSGG 
841:	QGSATGEIMY SPHEARTGSG LQGPAGGDGV GGAGGRTSSA DGLRPAASAE LGERTYSAAP 
901:	SSMGATNVAM IVMSPAEFDE FIADHPYTQR QYLRLQYRVR IFVNHNLFNQ FFMLLIFLNT 
961:	IFLSLEYHNQ PDSLTQALNV GNLTLTVLFT IEMVLKLFGL GFWDYIRDGF NIFDALVVTI 
1021:	SLLEIVLSSV GGLNAVRALR VLKALRVLRL FKLFRYMQSL RRIGEVLLSA ASSFMAIATL 
1081:	LILFWMVFAI VGMHVFGDKD LDTFPWPNFS TFLYSLVATW NVLNLENWQN IMYAVIRQTG 
1141:	YASSLFFVMW IIIGRYIFLT LFLAVTLEAF EAKYDPNAVR MGANKTGISS VLGSLRSGLS 
1201:	SLRSGMNSVR SSMRGSGKGR SPPDSPHGRK GGGGEGPKGG AGGAVTTAAK QPEQGKVPAG 
1261:	SGGKVTPATE VPSNIDDTRS DSEIGRDSEP VPPPSVLRPG IGYMADAQAA AAAAAAGNPE 
1321:	APRVNLKRMY TIKEWIDTGN FEVLKDGGAK DGAAAPAADG AAAAAASLSA AGAADALKAE 
1381:	PSTARSLKRE PSARLTGPSE PVAEGGSNKP ARGTSIIDDS AAQSLASSDA AGGNSASGEA 
1441:	KDVGATNGPA RPVAEGTETI RPDPTALPPS SSGGGGRSSL TGLRSNGGSP SPTWAGTGSR 
1501:	GRLESINRNI RRSLEGFAAE ADEEEGGDGD AAAGPRRHVL RGPSPLGGFA PSSTAAGSRN 
1561:	SASGMAAGSE LILTHGRTPA PLRGGGLSPD LMRMAGSFGD DSSTDDDDAK PGAGGPAGAA 
1621:	TAKTAAPVLA TAGSLNTPGL RSSATTTVTT ASAAEAQKLQ QQQQQQPLVT VESSEDPLGS 
1681:	FMDPLHLAQP HAGQPSAAGA AYGPAVAATS SIFLPSKPLP APQAYGILPG SPQPQLSLGL 
1741:	LSEPASGNDV VMATFGDMSS IFAQPHAEPQ QPQPQTQTQQ APPVNASRLS YELEGVDALA 
1801:	GWAGSAGNAH RARRSSTTVP RRHGGPAPAA AAEPQAGDRG VGSGAAPGSA EDDHLMALAG 
1861:	ELAAALKEQS VPQPAAPGDS DAVAAFRAQT LSAEPSAITT GGAVGWTSAS ETTSMQPTPR 
1921:	LKEPEAAAAA QPHADRPSAV PALHLERVAH GAPSTVPHAT AAAAAAAAAS SAFGSSGSKA 
1981:	SEVVPLGAAS LQDSAHSMSA SDLLGSGRRV IRAGGGAEGL LPKAPSTRLP PGEETLQNLD 
2041:	AYLPPGEALS RAATSNLAAR DADVKEAAAA SGLLADTLGE RIRTAAAAAR HTRGQTQEEE 
2101:	DELIFGLQPI RGSKDASRRS SQDDGAPRRP GSGRSGRDQK TPSPGPGGGK GDDEDGEDAG 
2161:	RQGDKGPPLQ RISESGSVAS RADSVNSHVS AGSRASSGGA TGTDDDGDEK SDKKRKHFRK 
2221:	KRRASILIEG SGKAFWIWDE DHPWRENTYW LVTHKRFEYT MFAVILANCV TLALENPYIV 
2281:	PGSPLDQALV WSNVGFTVIF GVEALLKSFA YTFTAYIKRV TNQVDFLIVV SSVVEIILLT 
2341:	ITTSVGAVSA LRVLRAFKPL RLLTRSAGMR LVFKSVTMSL MSMANVSVVC ILFFLIFAIL 
2401:	GVQLFSGRFY RCNDDTVAGQ TECVGNFTDP LTNSTLERHW SNDFPNFDNT GNALLCCFIT 
2461:	ATLNGYTEIM TNAMSAPQDV GLQPKQFINP GAFFWFFGFI VVCAFTLLNL YVGVIFSQFS 
2521:	KIRMLSETGS AFLTNDQNEW AELTKMVFRL KPPEKSHLPT SRLRRFCYQL VHHKYFDIFI 
2581:	LTIILINVGF LAATWYGEPP SYTRQKDLAN IVFMSVFAAE AVVKIFALGW MGYIKVSWNK 
2641:	LDFVLLVLGL LDLVVSMLQS NFLRILRVFR VQKLIALVRV ARFAQLVKSV KGIQSLFSTL 
2701:	VYSLPAFGNV GALIGLFFFM YAYVGTFLFG KVVGGETLNR SVNFHDFFQS LLVLTRVATG 
2761:	DNWTGVMFDC MVMPPDCDRA EGNCGSYLAI PYFLSFFLII SVILLNLFTA VIIETFEKTH 
2821:	EQEEWKLSPQ ALEDFVTLWS EYDDGSGTIQ PRHLEELLLK LDPPLGLGAY ADNKDVLRFV 
2881:	YDLDIPLVNG RVPFHKTAFE LVKRCSQATM PEGAIKEQID RLVDKFFHEL TAQDEMLNFS 
2941:	VAITVMKVQR KWRTRMRAAK LRRKNQWRKD RRDAPSYFDV STNKVSVGEK YEAYRDAQRE 
3001:	VAKTWEAAQV ASNKKVDKAE LARRSEPRWR FNPKYAPPSV VAATTEKTGL LGLGKRAINV 
3061:	NKLVGLFGLR GGLFGDGGDA DKGGRPPAAE FPAQLPD