1.A.1.11.33
Calcium channel protein of 2556 aas and 24 TMSs. Inhibited by 1,4-dihydrophyridines such as nifedipine (Tempone et al. 2009). The effects of nifedipine and calcium ions on cellular electrophysiology have been examined (Tsai et al. 2021).
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| Accession Number: | E9BQK4 |
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| Protein Name: | Calcium channel protein, putative |
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| Length: | 2556 |
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| Molecular Weight: | 291274.00 |
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| Species: | Leishmania donovani (strain BPK282A1) [981087] |
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| Number of TMSs: | 21 |
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| Substrate |
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1: MEIPLARTQP IEKFFVEYNS AAAEREDDGQ PRDDNEVLLM QFAEYTDDDS FFSSSDTVIE
61: CDPQRLRSDP LRRRAVVSVH NTLQLRALTN GRVPEDMVWN NVTRTSWLYQ IHNRAIALQH
121: SSFFIFPARW TPRVMVYNVM HHWLMEMFIF LMILGYAIFQ ATWSRYTAPP GGMHKPDHII
181: WADVFYTCLL GFEIIARLFA SGGILHKRAF FRSPWRWLDT AVLVLSIMEC TWWQDLWNFT
241: AWRLIRTIKC LTYVPAPVRM KLLAKSLLRS TNRLIYVTIF LTYFIFFFGL LGLQLFVGTL
301: HSRCVNTLTG AVTSQVCRSV ATGQYGFYWG HHCGVFYTCQ ADAFPNPHYD FRSFDDIGHA
361: MLSVFQIMTF QGWSELLQET NDGLAMMAFL YYFFTILVCA WIVPSLYLGV FLEKMDKTSR
421: LFVLKQLDFF DHMLTEQRQR MSSMVRLNDY VERDENGFVS HYPAYTLQQQ DDKRLTSDDS
481: TSGSTDDKNM NAHRIKSHHR AIQATKWTDE QRIQLQLALT RQRDVAEEAE RKRQLQQAAL
541: GDLIVEEGGA GKRQGTGRRG ASPAGAASGS ATQTETSPQP TKERSEFALG GRVGAVQHHP
601: AAYAIGDSHQ SDLPFAVRQE VQAEQLRFLD PYTNGASAAK NDMYNSAAAL RTSIDQSRTA
661: VPGGGAESAT VLHSRPVSNA RPSTRAPSAP STSVMVAREA AGVVPHRRST SVRGGTLSRA
721: SSMNGRGSLS RLHASMTQVP QAPTQQEQTA YVINDPEGGD FDYAKTLGQK INIIRNIAHM
781: FTEGYPRIIS QYLWEHRMMQ HRYGLTPLSY TNKYEEEALR RLRQRRAQER REEREELRRS
841: GMGHLIDDDE DEDDDSLAEK PWMRQEGLVP GSMSPIRMAR NIRENAPITV FNYIMYSFII
901: ANAVFNASRF DTMPDYWETG TFIAGVCFSV LFMLELLIRL LALGPGPFFT DIVILIEATF
961: MVTSLFQLGY SRANTTSLFN WVRFLRLFRV IPCRPLRRVS RVLIHGFPDM VYALVFFTLY
1021: MFMWLLLGMS FFGSRIGWID YNTSDYTTRG TFETFSHAAY AVAQAFSVNR DQWLYLSWSG
1081: MRVRGSYTVM YFIATVCVAF IFRFFFIAVM TCAWQAQQEK EDYYFMSGSS HGRRGRRSRF
1141: ARLPFFDFSV WRSFKHIHGG FDRRDVAPDE IYFLNEDMAR QLRLVEAKDR YYREHYGQEK
1201: SEWSDMGEGS QVGGSDMYGP DGALVNGPQY VNIGGRLYRQ PSLPATEMGF SVVGTPQQRG
1261: QLRFARHHRA VPATTYAAAQ LQRPAGAHDA LPDEVVGSRS LSRHSRRSMA NPLLADRHSL
1321: SPAHQGTSVG GPSVARVSDS LAEERAKNTN ISLVPRLTKL GNARALVVAG DDEATADYST
1381: PEGGVSDEDF EHLLLPGPRL RYKSTMDEGR RVFETCLDCN THMQMPLRAP PGVAQRTAEE
1441: LHAEHCHMAA VRSSQQLVLN ALIGYTRMQA DHEVTPTKRM VEIVLGQAWS CGMLLFDTIE
1501: NLSCMDLPEQ ERTWDRMLEA LEMQQWLLGL HVGEEQVGRA TLAYILANQQ RQEAQVREKS
1561: YKNTWEDRVF FVLSPSNPVR RAVSAVVGSM WFEIAVLCVV YAASICLAVY APDEGNRDFG
1621: GSYNSAKYKV LHILDDIFSI IFAVEMVLKW ISMGVVLPVG RAYFWHRWNI FDFFIVIISL
1681: VSWGRPDIFL RYLKVMRCFR ILGPLRYWKW GSSSMSHVAR AIWDSIPTLA NVCLLMLMNY
1741: IVWAIIFVSL FMDKFNYCSN ASIVNGTQCV EEGYTWAPTQ RNFRNFYESL LTTFEISTGA
1801: EWIDVIYSAV DSRSALLSPL RNQRPYLGLV FIAYYYVSHF IFFTLFISAV IYCYMLAKSA
1861: TEDATGTTIE HQVWLRMQGM IFRLKPKVQL LPLDTRVSRL VHFLISNRWF EAFMGLILVF
1921: NMLTMSLEWY QMSSTQKTTL DAFQYIWVVI FTLEVVLRFV AHGLRFFTRR AYCWDLLIVV
1981: LSYIQIGLST TATNRVPFNV NVLRMLRVGR VLHLVHLVLP FSTHLTLFHE VLKASVPGLI
2041: SVTFVYMIAV YVFAILGLHF LGYIVPFGGY IDDKYNNFGT FVNALIMVFR LSTLQNWATM
2101: LRGSLDRGYY CARASKRCGP TDWAPVYYIP IVICFFLLLS TLYMAVVLDK YVAAVRIYSA
2161: VTRLDELRRF CRLWSKRDPN GTMWLPSAVL PELLEELRLP LGVSDRRNRV EVMQLLREYN
2221: IPDHNGRVYY YEVLLPLARR VMAIAFLEAA DAHTAGSQAP RDIAWHLSER SLGALPASYG
2281: TVRPSSVTVA EHYAAALLQA AFRRDRAMRD YYIAKSELWR RGRAVCVERG LPYDNFGFGK
2341: TPLAGPDPRE EGMRRGFNIP KDATLANSAG GRVYADPVAA RIAAMREAMG SHKRATDQEP
2401: PTLLPAVYRS AIYPEEKRFG PNAPGAIRRH ERRDEKLERK RAQEEYERQM YERSTRGCPA
2461: RTAGEQKDNE TVTAEGAGDV DVGLAYSKGT MEPHPAARGN QYNLDPMDVN YQPPLGTSPE
2521: ELRQEKVDRR LNAAAAAATA SATLGGISPS TTPEQY