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1.A.1.15.5
The KCNQ5 K+ channel (modulated by Zn2+ , pH and volume change) (Jensen et al., 2005).  A triple cysteine module within M-type K+ channels mediates reciptrocal channel modulation by nitric oxide and reactive oxygen species (Ooi et al. 2013). Gabapentin at low concentrations is a activator of KCNQ3, KCNQ2/3 and KCNQ5 but not of KCNQ2 or KCNQ4 (Manville and Abbott 2018). At high concentrations, it can be inhibitory.  KCNQ5 controls perivascular adipose tissue-mediated vasodilation (Tsvetkov et al. 2024).

Accession Number:Q9JK45
Protein Name:Potassium voltage-gated channel subfamily aka KCNQ5
Length:933
Molecular Weight:102258.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate potassium(1+)

Cross database links:

RefSeq: NP_076361.1   
Entrez Gene ID: 226922   
Pfam: PF00520    PF03520   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005249 F:voltage-gated potassium channel activity
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes.”  Jensen H.S.et.al.   15963599
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPRHHAGGEE GGAAGLWVRS GAAAAAGAGG GRPGSGMKDV ESGRGRVLLN SAAARGDGLL 
61:	LLGTRAAALG GGGGGLRESR RGKQGARMSL LGKPLSYTSS QSCRRNVKYR RVQNYLYNVL 
121:	ERPRGWAFVY HAFVFLLVFG CLILSVFSTI PEHTKLASSC LLILEFVMIV VFGLEFIIRI 
181:	WSAGCCCRYR GWQGRLRFAR KPFCVIDTIV LIASIAVVSA KTQGNIFATS ALRSLRFLQI 
241:	LRMVRMDRRG GTWKLLGSVV YAHSKELITA WYIGFLVLIF SSFLVYLVEK DANKEFSTYA 
301:	DALWWGTITL TTIGYGDKTP LTWLGRLLSA GFALLGISFF ALPAGILGSG FALKVQEQHR 
361:	QKHFEKRRNP AANLIQCVWR SYAADEKSVS IATWKPHLKA LHTCSPTKKE QGEASSSQKL 
421:	SFKERVRMAS PRGQSIKSRQ ASVGDRRSPS TDITAEGSPT KVQKSWSFND RTRFRPSLRL 
481:	KSSQPKPVID ADTALGIDDV YDEKGCQCDV SVEDLTPPLK TVIRAIRIMK FHVAKRKFKE 
541:	TLRPYDVKDV IEQYSAGHLD MLCRIKSLQT RVDQILGKGQ MTSDKKSREK ITAEHETTDD 
601:	PSMLARVVKV EKQVQSIESK LDCLLDIYQQ VLRKGSASAL TLASFQIPPF ECEQTSDYQS 
661:	PVDSKDLSGS AQNSGCLTRS ASANISRGLQ FILTPNEFSA QTFYALSPTM HSQATQVPMS 
721:	QNDGSSVVAT NNIANQISAA PKPAAPTTLQ IPPPLSAIKH LSRPEPLLSN PTGLQESISD 
781:	VTTCLVASKE SVQFAQSNLT KDRSLRKSFD MGGETLLSVR PMVPKDLGKS LSVQNLIRST 
841:	EELNLQFSGS ESSGSRGSQD FYPKWRESKL FITDEEVGAE ETETDTFDGT PPPAGEAAFS 
901:	SDSLRTGRSR SSQNICKTGD STDALSLPHV KLN