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1.A.1.19.2
Sperm-associated cation channel, CatSper2 with 530 aas and 6 TMSs; it is a voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte (Strünker et al. 2011). The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (Lishko et al. 2011).

Accession Number:Q96P56
Protein Name:Cation channel sperm-associated protein 2
Length:530
Molecular Weight:62041.00
Species: [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell projection1 / Multi-pass membrane protein2
Substrate calcium(2+)

Cross database links:

RefSeq: NP_473361.1    NP_742093.1    NP_742095.1   
Entrez Gene ID: 117155   
Pfam: PF00520   
OMIM: 607249  gene
611102  phenotype
KEGG: hsa:117155   

Gene Ontology

GO:0005929 C:cilium
GO:0020017 C:flagellar membrane
GO:0016021 C:integral to membrane
GO:0005262 F:calcium channel activity
GO:0005515 F:protein binding
GO:0005244 F:voltage-gated ion channel activity
GO:0006816 P:calcium ion transport
GO:0030154 P:cell differentiation
GO:0007275 P:multicellular organismal development
GO:0007283 P:spermatogenesis
GO:0055085 P:transmembrane transport

References (6)

[1] “A voltage-gated ion channel expressed specifically in spermatozoa.”  Quill T.A.et.al.   11675491
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “CATSPER2, a human autosomal nonsyndromic male infertility gene.”  Avidan N.et.al.   12825070
[4] “Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.”  Zhang D.et.al.   16740636
[5] “Sensorineural deafness and male infertility: a contiguous gene deletion syndrome.”  Zhang Y.et.al.   17098888
[6] “Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility.”  Li H.-G.et.al.   17347248

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAYQQEEQM QLPRADAIRS RLIDTFSLIE HLQGLSQAVP RHTIRELLDP SRQKKLVLGD 
61:	QHQLVRFSIK PQRIEQISHA QRLLSRLHVR CSQRPPLSLW AGWVLECPLF KNFIIFLVFL 
121:	NTIILMVEIE LLESTNTKLW PLKLTLEVAA WFILLIFILE ILLKWLSNFS VFWKSAWNVF 
181:	DFVVTMLSLL PEVVVLVGVT GQSVWLQLLR ICRVLRSLKL LAQFRQIQII ILVLVRALKS 
241:	MTFLLMLLLI FFYIFAVTGV YVFSEYTRSP RQDLEYHVFF SDLPNSLVTV FILFTLDHWY 
301:	ALLQDVWKVP EVSRIFSSIY FILWLLLGSI IFRSIIVAMM VTNFQNIRKE LNEEMARREV 
361:	QLKADMFKRQ IIQRRKNMSH EALTSSHSKI EDSSRGASQQ RESLDLSEVS EVESNYGATE 
421:	EDLITSASKT EETLSKKREY QSSSCVSSTS SSYSSSSESR FSESIGRLDW ETLVHENLPG 
481:	LMEMDQDDRV WPRDSLFRYF ELLEKLQYNL EERKKLQEFA VQALMNLEDK