1.A.1.2.20
Shaker K+ channel, Shk-1, Shk1, Kv1 of 536 aas and 6 TMSs. Mediates
the voltage-dependent potassium ion permeability of excitable
membranes. It plays a role in repolarization and in regulating the
pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d (Liu et al. 2011).
|
| Accession Number: | Q8I4B0 |
|---|
| Protein Name: | Potassium voltage-gated channel protein shk-1 |
|---|
| Length: | 536 |
|---|
| Molecular Weight: | 61234.00 |
|---|
| Species: | Caenorhabditis elegans [6239] |
|---|
| Number of TMSs: | 7 |
|---|
| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
potassium(1+) |
|---|
1: MRFGGQRRCI ESSDDNDSID SMSIQQKNKE KEEWKWAQSL ARRLEQVLNV HPEKYQNGCS
61: SQRPSRQPSP VEQLAPIRSH SADFGRAAEM ASGNSEEGKG MLLRNGDDRI RLPSPQRGTP
121: DTSSTQGHPY TDQIVTINVS GMRFQTFEST LSRYPNSLLG DRNKRQHFFV SDTNEFFFDR
181: HRTTSSSFTF EIRNYLFESI LYIYQSGGRV KRPEIVPIDI FLKEMRFFQM GDDLLEEFWI
241: AEGYEKPKEV MMPNNKTQRK IWELMEYPDS SLSARIIAFI SIAVIALSII SFCWETVPSD
301: IEEKPINNSA TAELLDEMDE KHYSPFFWIE LMCILWFTIE LILRFISCPC KVTFATSVLN
361: IIDFVAIAPF FVNFFFADTS KSNSSMSFAV LRVLRLVRVF RVFKLSRHSV GLQILGKTFR
421: SSVQEFCLLI FFMAIALVLF ASGMYFAEQG EPNSKFTSIP ASFWFVLVTM TTVGYGDLVP
481: LSPFGKVVGG MCAMIGVLTL ALPVPIIVAN FKHFYRQENR LASMKSKGDD ADDDIA