1.A.1.2.27
Potassium voltage-gated channel subfamily G member 1, KCNG1, of 513 aas and 6 TMSs. Expressed in brain and placenta, and at much lower levels in kidney and pancreas (Su et al. 1997). This potassium channel subunit does not
form functional channels by itself, but can form functional heterotetrameric
channels with KCNB1. It modulates the delayed rectifier voltage-gated
potassium channel activation and deactivation rates of KCNB1 (Mederos Y Schnitzler et al. 2009). KCNG1 mutations cause a syndromic form of congenital neuromuscular channelopathy (Jacinto et al. 2021).
|
| Accession Number: | Q9UIX4 |
|---|
| Protein Name: | Potassium voltage-gated channel subfamily G member 1 |
|---|
| Length: | 513 |
|---|
| Molecular Weight: | 57913.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 4 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
|
|---|
1: MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD EPRQGCQPED
61: RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD ILNVCDDYDV TCNEFFFDRN
121: PGAFGTILTF LRAGKLRLLR EMCALSFQEE LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV
181: EREEEDDALD SEGRDSEGPA EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT
241: AVNLSVSTLP SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP
301: LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI LYVMRLARHS
361: LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN EMADSPEFTS IPACYWWAVI
421: TMTTVGYGDM VPRSTPGQVV ALSSILSGIL LMAFPVTSIF HTFSRSYLEL KQEQERVMFR
481: RAQFLIKTKS QLSVSQDSDI LFGSASSDTR DNN