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1.A.1.4.1
K+ channel, AKT1; may form heteromeric channels with KC1 (TC # 1.A.1.4.9) (Geiger et al., 2009).  Required for seed development and postgermination growth in low potassium (Pyo et al. 2010).  Functions optimally with intermediate potassium concentrations (~1 mM) (Nieves-Cordones et al. 2014). In barley, it may play a role in drought resistance (Cai et al. 2019).  HAK/KUP/KT8, GrAKT2.1 and GrAKT1.1 potassium channels may function in response to abiotic stress in Gossypium raimondii (Azeem et al. 2021). Plants obtain nutrients from the soil via transmembrane transporters and channels in their root hairs, from which ions radially transport in toward the xylem for distribution across the plant body. Dickinson et al. 2021 determined structures of the hyperpolarization-activated channel, AKT1, from Arabidopsis thaliana, which mediates K+ uptake from the soil into plant roots. The structures of AtAKT1, embedded in lipid nanodiscs, show that the channel undergoes a reduction of C4 to C2 symmetry, possibly to regulate its electrical activation.  

Accession Number:Q38998
Protein Name:AKT1 or F18A8.2
Length:857
Molecular Weight:96990.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

DIP: DIP-36762N
RefSeq: NP_180233.1   
Entrez Gene ID: 817206   
Pfam: PF00023    PF00027    PF11834    PF00520   
BioCyc: MetaCyc:MONOMER-14552   
KEGG: ath:AT2G26650   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005242 F:inward rectifier potassium channel activity
GO:0005515 F:protein binding
GO:0006813 P:potassium ion transport
GO:0009651 P:response to salt stress
GO:0048767 P:root hair elongation
GO:0055085 P:transmembrane transport

References (12)

[1] “Cloning and expression in yeast of a plant potassium ion transport system.”  Sentenac H.et.al.   1585180
[2] “Organization and expression of the gene coding for the potassium transport system AKT1 of Arabidopsis thaliana.”  Basset M.et.al.   8555458
[3] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[4] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[5] “Tissue-specific expression of Arabidopsis AKT1 gene is consistent with a role in K+ nutrition.”  Lagarde D.et.al.   8820606
[6] “Tetramerization of the AKT1 plant potassium channel involves its C-terminal cytoplasmic domain.”  Daram P.et.al.   9218788
[7] “A role for the AKT1 potassium channel in plant nutrition.”  Hirsch R.E.et.al.   9572739
[8] “Phylogenetic relationships within cation transporter families of Arabidopsis.”  Maeser P.et.al.   11500563
[9] “Regulated expression of Arabidopsis shaker K(+) channel genes involved in K(+) uptake and distribution in the plant.”  Pilot G.et.al.   12678562
[10] “A protein kinase, interacting with two calcineurin B-like proteins, regulates K+ transporter AKT1 in Arabidopsis.”  Xu J.et.al.   16814720
[11] “A Ca(2)+ signaling pathway regulates a K(+) channel for low-K response in Arabidopsis.”  Li L.et.al.   16895985
[12] “A protein phosphorylation/dephosphorylation network regulates a plant potassium channel.”  Lee S.-C.et.al.   17898163
Structure:
5AAR     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MRGGALLCGQ VQDEIEQLSR ESSHFSLSTG ILPSLGARSN RRVKLRRFVV SPYDHKYRIW 
61:	EAFLVVLVVY TAWVSPFEFG FLRKPRPPLS ITDNIVNAFF AIDIIMTFFV GYLDKSTYLI 
121:	VDDRKQIAFK YLRSWFLLDL VSTIPSEAAM RISSQSYGLF NMLRLWRLRR VGALFARLEK 
181:	DRNFNYFWVR CAKLVCVTLF AVHCAACFYY LIAARNSNPA KTWIGANVAN FLEESLWMRY 
241:	VTSMYWSITT LTTVGYGDLH PVNTKEMIFD IFYMLFNLGL TAYLIGNMTN LVVHGTSRTR 
301:	NFRDTIQAAS NFAHRNHLPP RLQDQMLAHL CLKYRTDSEG LQQQETLDAL PKAIRSSISH 
361:	FLFYSLMDKV YLFRGVSNDL LFQLVSEMKA EYFPPKEDVI LQNEAPTDFY ILVNGTADLV 
421:	DVDTGTESIV REVKAGDIIG EIGVLCYRPQ LFTVRTKRLC QLLRMNRTTF LNIIQANVGD 
481:	GTIIMNNLLQ HLKEMNDPVM TNVLLEIENM LARGKMDLPL NLCFAAIRED DLLLHQLLKR 
541:	GLDPNESDNN GRTPLHIAAS KGTLNCVLLL LEYHADPNCR DAEGSVPLWE AMVEGHEKVV 
601:	KVLLEHGSTI DAGDVGHFAC TAAEQGNLKL LKEIVLHGGD VTRPRATGTS ALHTAVCEEN 
661:	IEMVKYLLEQ GADVNKQDMH GWTPRDLAEQ QGHEDIKALF REKLHERRVH IETSSSVPIL 
721:	KTGIRFLGRF TSEPNIRPAS REVSFRIRET RARRKTNNFD NSLFGILANQ SVPKNGLATV 
781:	DEGRTGNPVR VTISCAEKDD IAGKLVLLPG SFKELLELGS NKFGIVATKV MNKDNNAEID 
841:	DVDVIRDGDH LIFATDS