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1.A.1.5.26
Cyclic nuceotide gated channel of 706 aas, CNGC18.  It is the essential Ca2+ channel for pollen tube guidance (Gao et al. 2016). MLO5 and MLO9 selectively recruit the Ca2+ channel CNGC18-containing vesicles to the plasma membrane through the R-SNARE proteins, VAMP721 and VAMP722 in trans mode. Meng et al. 2020 identified members of the conserved 7 TMS MLO family (expressed in the pollen tube) as tethering factors for Ca2+ channels, revealing a mechanism of molecular integration of extracellular ovular cues and selective exocytosis. This work sheds light on the general regulation of MLO proteins in cell responses to environmental stimuli (Meng et al. 2020).

Accession Number:Q9LEQ3
Protein Name:Putative cyclic nucleotide-gated ion channel 18
Length:706
Molecular Weight:80364.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Ca2+

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKIRSLRCL LPETITSAST AASNRGSDGS QFSVLWRHQI LDPDSNIVTY WNHVFLITSI 
61:	LALFLDPFYF YVPYVGGPAC LSIDISLAAT VTFFRTVADI FHLLHIFMKF RTAFVARSSR 
121:	VFGRGELVMD SREIAMRYLK TDFLIDVAAM LPLPQLVIWL VIPAATNGTA NHANSTLALI 
181:	VLVQYIPRSF IIFPLNQRII KTTGFIAKTA WAGAAYNLLL YILASHVLGA MWYLSSIGRQ 
241:	FSCWSNVCKK DNALRVLDCL PSFLDCKSLE QPERQYWQNV TQVLSHCDAT SSTTNFKFGM 
301:	FAEAFTTQVA TTDFVSKYLY CLWWGLRNLS SYGQNITTSV YLGETLFCIT ICIFGLILFT 
361:	LLIGNMQSSL QSMSVRVEEW RVKRRDTEEW MRHRQLPPEL QERVRRFVQY KWLATRGVDE 
421:	ESILHSLPTD LRREIQRHLC LSLVRRVPFF SQMDDQLLDA ICGCLVSSLS TAGTYIFREG 
481:	DPVNEMLFVI RGQIESSTTN GGRSGFFNST TLRPGDFCGE ELLTWALMPN STLNLPSSTR 
541:	SVRALSEVEA FALSAEDLKF VAHQFKRLQS KKLQHAFRYY SHQWRAWGAC FVQSAWRRYK 
601:	RRKLAKELSL HESSGYYYPD ETGYNEEDEE TREYYYGSDE EGGSMDNTNL GATILASKFA 
661:	ANTRRGTNQK ASSSSTGKKD GSSTSLKMPQ LFKPDEPDFS IDKEDV