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1.A.1.5.5
The cyclic nucleotide- and voltage-gated ion (K+, Rb+, Cs+) channel, CNGC1 (inward rectifying). It functions in heavy metal and cation transport, as does CNGC10 (Dreyer and Uozumi, 2011; Zelman et al., 2012).  143 CNGC genes in Glycine max have been identified and classified, and they have been screened for related resistance genes after Fusarium solani infection (Cui et al. 2023).

Accession Number:O65717
Protein Name:Cyclic nucleotide-gated ion channel 1 aka CNGC1
Length:716
Molecular Weight:83097.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate potassium(1+), rubidium(1+), caesium(1+)

Cross database links:

RefSeq: NP_200125.1   
Entrez Gene ID: 835393   
Pfam: PF00027    PF00520   
KEGG: ath:AT5G53130   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005516 F:calmodulin binding
GO:0030552 F:cAMP binding
GO:0030553 F:cGMP binding
GO:0005221 F:intracellular cyclic nucleotide activated c...
GO:0006816 P:calcium ion transport
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[2] “Characterisation of a novel gene family of putative cyclic nucleotide- and calmodulin-regulated ion channels in Arabidopsis thaliana.”  Koehler C.et.al.   10341447
[3] “Characterisation of calmodulin binding to cyclic nucleotide-gated ion channels from Arabidopsis thaliana.”  Koehler C.et.al.   10767408
[4] “Expression of a truncated tobacco NtCBP4 channel in transgenic plants and disruption of the homologous Arabidopsis CNGC1 gene confer Pb2+ tolerance.”  Sunkar R.et.al.   11115134
[5] “Phylogenetic relationships within cation transporter families of Arabidopsis.”  Maeser P.et.al.   11500563
[6] “Electrophysiological analysis of cloned cyclic nucleotide-gated ion channels.”  Leng Q.et.al.   11842144

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNFRQEKFVR FQDWKSDKTS SDVEYSGKNE IQTGIFQRTI SSISDKFYRS FESSSARIKL 
61:	FKRSYKSYSF KEAVSKGIGS THKILDPQGP FLQRWNKIFV LACIIAVSLD PLFFYVPIID 
121:	DAKKCLGIDK KMEITASVLR SFTDVFYVLH IIFQFRTGFI APSSRVFGRG VLVEDKREIA 
181:	KRYLSSHFII DILAVLPLPQ MVILIIIPHM RGSSSLNTKN MLKFIVFFQY IPRFIRIYPL 
241:	YKEVTRTSGI LTETAWAGAA FNLFLYMLAS HVFGAFWYLF SIERETVCWK QACERNNPPC 
301:	ISKLLYCDPE TAGGNAFLNE SCPIQTPNTT LFDFGIFLDA LQSGVVESQD FPQKFFYCFW 
361:	WGLQNLSSLG QNLKTSTYIW EICFAVFISI AGLVLFSFLI GNMQTYLQST TTRLEEMRVK 
421:	RRDAEQWMSH RLLPENLRKR IRRYEQYKWQ ETRGVDEENL LSNLPKDLRR DIKRHLCLAL 
481:	LMRVPMFEKM DEQLLDALCD RLQPVLYTEE SYIVREGDPV DEMLFIMRGK LLTITTNGGR 
541:	TGFLNSEYLG AGDFCGEELL TWALDPHSSS NLPISTRTVR ALMEVEAFAL KADDLKFVAS 
601:	QFRRLHSKQL RHTFRYYSQQ WKTWAACFIQ AAWRRYIKKK LEESLKEEEN RLQDALAKEA 
661:	CGSSPSLGAT IYASRFAANI LRTIRRSGSV RKPRMPERMP PMLLQKPAEP DFNSDD