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1.A.1.5.7 The cyclic nucleotide-gated ion (K⁺, Rb⁺, Cs⁺) channel, HLM1 (CNGC4) It mediates the hypersensitive response (HR) of plants in programmed cell death. Mutants show abnormal cell death and resistance to infection by Pseudomonas syringae (Balagué et al., 2003; Zelman et al., 2012).
Accession Number:	Q94AS9
Protein Name:	Cyclic nucleotide-gated ion channel 4 aka CNGC4 aka HLM1
Length:	694
Molecular Weight:	80081.00
Species:	Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:	7
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	potassium(1+), rubidium(1+), caesium(1+)

RefSeq:	NP_200236.1 NP_851188.1
Entrez Gene ID:	835513
Pfam:	PF00027
KEGG:	ath:AT5G54250
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0005516 F:calmodulin binding GO:0030552 F:cAMP binding GO:0008324 F:cation transmembrane transporter activity GO:0030553 F:cGMP binding GO:0005216 F:ion channel activity GO:0006811 P:ion transport GO:0009626 P:plant-type hypersensitive response
References (5) [1] “Characterisation of a novel gene family of putative cyclic nucleotide- and calmodulin-regulated ion channels in Arabidopsis thaliana.” Koehler C.et.al. 10341447 [2] “Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.” Kaneko T.et.al. 9679202 [3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.” Yamada K.et.al. 14593172 [4] “Phylogenetic relationships within cation transporter families of Arabidopsis.” Maeser P.et.al. 11500563 [5] “HLM1, an essential signaling component in the hypersensitive response, is a member of the cyclic nucleotide-gated channel ion channel family.” Balague C.et.al. 12566578

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FASTA formatted sequence

1:	MATEQEFTRA SRFSRDSSSV GYYSEEDNTE EEDEEEEEME EIEEEEEEEE EEDPRIGLTC 
61:	GGRRNGSSNN NKWMMLGRIL DPRSKWVREW NKVFLLVCAT GLFVDPLFLY TLSVSDTCMC 
121:	LLVDGWLALT VTALRSMTDL LHLWNIWIQF KIARRWPYPG GDSDGDTNKG GGTRGSTRVA 
181:	PPYVKKNGFF FDLFVILPLP QVVLWVVIPS LLKRGSVTLV VSVLLVTFLF QYLPKIYHSI 
241:	RHLRRNATLS GYIFGTVWWG IALNMIAYFV AAHAAGACWY LLGVQRSAKC LKEQCENTIG 
301:	CDLRMLSCKE PVYYGTTVMV LDRARLAWAQ NHQARSVCLD INTNYTYGAY QWTIQLVSSE 
361:	SRLEKILFPI FWGLMTLSTF GNLESTTEWS EVVFNIIVLT SGLLLVTMLI GNIKVFLHAT 
421:	TSKKQAMHLK MRNIEWWMKK RHLPIGFRQR VRNYERQRWA AMRGVDECEM VQNLPEGLRR 
481:	DIKYHLCLDL VRQVPLFQHM DDLVLENICD RVKSLIFTKG ETIQKEGDAV QRMLFVVRGH 
541:	LQSSQLLRDG VKSCCMLGPG NFSGDELLSW CLRRPFVERL PPSSSTLVTL ETTEAFGLDA 
601:	EDVKYVTQHF RYTFVNEKVK RSARYYSPGW RTWAAVAVQL AWRRYKHRLT LTSLSFIRPR 
661:	RPLSRCASLG EDKLRLYAAI LTSPKPNPDD FDDY

1.A.1.5.7
The cyclic nucleotide-gated ion (K⁺, Rb⁺, Cs⁺) channel, HLM1 (CNGC4) It mediates the hypersensitive response (HR) of plants in programmed cell death. Mutants show abnormal cell death and resistance to infection by Pseudomonas syringae (Balagué et al., 2003; Zelman et al., 2012).

Cross database links:

Gene Ontology

References (5)

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1.A.1.5.7The cyclic nucleotide-gated ion (K+, Rb+, Cs+) channel, HLM1 (CNGC4) It mediates the hypersensitive response (HR) of plants in programmed cell death. Mutants show abnormal cell death and resistance to infection by Pseudomonas syringae (Balagué et al., 2003; Zelman et al., 2012).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

1.A.1.5.7
The cyclic nucleotide-gated ion (K⁺, Rb⁺, Cs⁺) channel, HLM1 (CNGC4) It mediates the hypersensitive response (HR) of plants in programmed cell death. Mutants show abnormal cell death and resistance to infection by Pseudomonas syringae (Balagué et al., 2003; Zelman et al., 2012).