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Accession Number: | O95279 |
Protein Name: | TASK2 aka KCNK5 |
Length: | 499 |
Molecular Weight: | 55130.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 5 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | lithium(1+), sodium(1+), potassium(1+), rubidium(1+), caesium(1+), ammonium |
Cross database links:
RefSeq: | NP_003731.1 |
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Entrez Gene ID: | 8645 |
Pfam: | PF07885 |
OMIM: |
603493 gene |
KEGG: | hsa:8645 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005267
F:potassium channel activity
GO:0005244
F:voltage-gated ion channel activity
GO:0007588
P:excretion
GO:0006813
P:potassium ion transport
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References (6)[1] “Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney.” Reyes R.et.al. 9812978 [2] “Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.” Gierten J.et.al. 18516069 [3] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity.” Niemeyer M.I.et.al. 12851074 [6] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.” Daub H.et.al. 18691976
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External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MVDRGPLLTS AIIFYLAIGA AIFEVLEEPH WKEAKKNYYT QKLHLLKEFP CLGQEGLDKI 61: LEVVSDAAGQ GVAITGNQTF NNWNWPNAMI FAATVITTIG YGNVAPKTPA GRLFCVFYGL 121: FGVPLCLTWI SALGKFFGGR AKRLGQFLTK RGVSLRKAQI TCTVIFIVWG VLVHLVIPPF 181: VFMVTEGWNY IEGLYYSFIT ISTIGFGDFV AGVNPSANYH ALYRYFVELW IYLGLAWLSL 241: FVNWKVSMFV EVHKAIKKRR RRRKESFESS PHSRKALQVK GSTASKDVNI FSFLSKKEET 301: YNDLIKQIGK KAMKTSGGGE TGPGPGLGPQ GGGLPALPPS LVPLVVYSKN RVPTLEEVSQ 361: TLRSKGHVSR SPDEEAVARA PEDSSPAPEV FMNQLDRISE ECEPWDAQDY HPLIFQDASI 421: TFVNTEAGLS DEETSKSSLE DNLAGEESPQ QGAEAKAPLN MGEFPSSSES TFTSTESELS 481: VPYEQLMNEY NKANSPKGT