1.A.10.1.26
Ionotropic receptor 21a, Ir21a, of 842 aas and 5 TMSs. Ir21a is a cooling receptor that drives heat seaking in insects to their warm blooded hosts (Greppi et al. 2020). Although Ir21a mediates heat avoidance in Drosophila, it drives heat seeking and heat-stimulated blood feeding in Anopheles. At a cellular level, Ir21a is essential for the detection of cooling, suggesting that during
evolution, mosquito heat seeking relied on cooling-mediated repulsion.
Thus, the evolution of blood feeding in Anopheles involves repurposing an ancestral thermoreceptor from non-blood-feeding Diptera (Greppi et al. 2020).
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| Accession Number: | Q9VPI2 |
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| Protein Name: | Ionotropic receptor 21a |
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| Length: | 842 |
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| Molecular Weight: | 95565.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSYYWVALVL FTAQAFSIEG DRSASYQEKC ISRRLINHYQ LNKEIFGVGM CDGNNENEFR
61: QKRRIVPTFQ GNPRPRGELL ASKFHVNSYN FEQTNSLVGL VNKIAQEYLN KCPPVIYYDS
121: FVEKSDGLIL ENLFKTIPIT FYHGEINADY EAKNKRFTSH IDCNCKSYIL FLSDPLMTRK
181: ILGPQTESRV VLVSRSTQWR LRDFLSSELS SNIVNLLVIG ESLMADPMRE RPYVLYTHKL
241: YADGLGSNTP VVLTSWIKGA LSRPHINLFP SKFQFGFAGH RFQISAANQP PFIFRIRTLD
301: SSGMGQLRWD GVEFRLLTMI SKRLNFSIDI TETPTRSNTR GVVDTIQEQI IERTVDIGMS
361: GIYITQERLM DSAMSVGHSP DCAAFITLAS KALPKYRAIM GPFQWPVWVA LICVYLGGIF
421: PIVFTDRLTL SHLMGNWGEV ENMFWYVFGM FTNAFSFTGK YSWSNTRKNS TRLLIGAYWL
481: FTIIITSCYT GSIIAFVTLP AFPDTVDSVL DLLGLFFRVG TLNNGGWETW FQNSTHIPTS
541: RLYKKMEFVG SVDEGIGNVT QSFFWNYAFL GSKAQLEYLV QSNFSDENIS RRSALHLSEE
601: CFALFQIGFL FPRESVYKIK IDSMILLAQQ SGLIAKINNE VSWVMQRSSS GRLLQASSSN
661: SLREIIQEER QLTTADTEGM FLLMALGYFL GATALVSEIV GGITNKCRQI IKRSRKSAAS
721: SWSSASSGSM LRTNAEQLSH DKRKANRREA AEVAQKMSFG MRELNLTRAT LREIYGSYGA
781: PETDHGQLDI VHTEFPNSSA KLNNIEDEES REALESLQRL DEFMDQMDND GNPSSHTFRI
841: DN