| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.A.108.1.1 | Fibroblast growth factor 2, FGF2, of 288 aas. Forms oligomeric pores in the plasma membrane, and these are involved in its secretion to the external medium where it exerts its action (La Venuta et al. 2016; see family description). The ATP1A1 (TC# 3.A.3.1.1) serves as the receptor for membrane insertion (Zacherl et al. 2015). | Eukaryota |
Metazoa, Chordata | FGF2 of Homo sapiens |
|
1.A.108.1.2 | Fibroblast growth factor 23, FGF23 of 251 aas. Functions through FGF receptor 4 to regulate the level of the calcium/inorganic cation channel, TrpC6 or TRP6 (TC# 1.A.4.1.5) (Smith et al. 2017). | Eukaryota |
Metazoa, Chordata | FGF23 of Homo sapiens |
|
1.A.108.1.3 | Fibroblast growth factor 14 (Fgf14) of 247 aas and possibly one central TMS. FGF14 is important in regulating the distribution of voltage-gated sodium channels in cerebellar Purkinje and granule cells (Graves et al. 2024). Mutations may be a cause of episodic ataxias (EAs) (Graves et al. 2024). | Eukaryota |
Metazoa, Chordata | Fgf14 of Homo sapiens |