TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
1.A.109.1.1 | Interleukin-1 alpha, IL1α or IL1A, of 271 aas and 0 TMSs. Regulates gap junctional communication in Sertoli cells, which is critical for sertoli cell barrier/blood-testis barrier (BTB) restructuring (Chojnacka et al. 2016). | Eukaryota |
Metazoa | IL1α of Homo sapiens |
1.A.109.1.2 | Interleukin 1β, IL1β, IL1beta, IL1B, IL1F2, of 269 aas. Its release depends on its insertion into the membrane with the formation of a transmembrane pore (Martín-Sánchez et al. 2016). IL-1beta is generated by macrophages upon activation of intracellular NLRP3 (NOD-like, leucine rich repeat domains, and pyrin domain-containing protein 3), part of the functional NLRP3 inflammasome complex that detects pathogenic microorganisms and stressors, while neutrophils are enhanced by increasing levels of IL-1beta (Yaqinuddin and Kashir 2020). | Eukaryota |
Metazoa | IL1beta of Homo sapiens |