TCDB is operated by the Saier Lab Bioinformatics Group

Short putative ORF10 protein of 38 aas and 1 N-terminal TMS. This protein has been shown to be a viroporin that is inhibited by Amantadine (Toft-Bertelsen et al. 2021). Amantadine blocks the ion channel activity of ORF10 (Toft-Bertelsen et al. 2021).  See family description for details. A cell-based system combined with flow cytometry has been used to evaluate antibody responses against SARS-CoV-2 transmembrane proteins in patients with COVID-19 (Martin et al. 2022).

Orthornavirae, Pisuviricota
ORF10 protein of severe acute respiratory syndrome coronavirus 2, SARS-CoV-2