1.A.14.3.12
Viroporin, pUS21, of 243 aas and 8 TMSs. It modulates calcium ion homeostasis and protects cells against apoptosis (Luganini et al. 2018). pUS21 of HCMV constitutes a TMBIM-derived viroporin that may contribute to HCMV's overall strategy to counteract apoptosis of infected cells.
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| Accession Number: | F5HHT6 |
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| Protein Name: | Membrane protein US21 |
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| Length: | 243 |
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| Molecular Weight: | 26927.00 |
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| Species: | Human cytomegalovirus (strain Merlin) (HHV-5) [295027] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Host membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSLRGQVQIA RSVFLLRIYI LIWVQCLILM SVCAFCWLVL PHRLEQLFSS VRLTLSCLMI
61: SIVCLGLLRW AEPNFPKNVW ILLTYTLLTS VAVTASGFHF SHRSVIYAMV ATVTLFCFLT
121: LATYLFARDV ELQRSLLTGA STLILLLFAV FSLFPEAVSE ILVMIAGLAV IVTSVVCDTQ
181: DILHDIEYES YIPGALCLYM DLMYLFVSVL YFMPSEPGSA HTAQTTVAAT VAATAAASPQ
241: FVS