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1.A.14.3.16
Protein lifeguard-2, Fas-apoptotic inhibitory molecule 2 (FAIM2) is of 316 aas with 7 TMSs. It is an antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis and regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation (Somia et al. 1999; Fernández et al. 2007). It is a member of the transmembrane BAX inhibitor motif-containing (TMBIM) family. The TMBIM family is comprised of six anti-apoptotic proteins that suppress cell death by regulating endoplasmic reticulum Ca2+ homeostasis. It localizes to the lysosome and facilitates autophagosome-lysosome fusion through the LC3 interaction region (Hong et al. 2020).

Accession Number:Q9BWQ8
Protein Name:Protein lifeguard 2
Length:316
Molecular Weight:35110.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE ATSGEGMKAG AFPPAPTAVP 
61:	LHPSWAYVDP SSSSSYDNGF PTGDHELFTT FSWDDQKVRR VFVRKVYTIL LIQLLVTLAV 
121:	VALFTFCDPV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTVFTLSMA 
181:	YLTGMLSSYY NTTSVLLCLG ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI 
241:	LAILLPFQYV PWLHAVYAAL GAGVFTLFLA LDTQLLMGNR RHSLSPEEYI FGALNIYLDI 
301:	IYIFTFFLQL FGTNRE