1.A.154. The Tentonin or TMEM150 (TMEM150) Family
Tentonin proteins (TMEM150) were orignally shown to be regulators of Piezo1 and Piezo2, and were therefore listed as members of TC family 8.A.113 but subsequently were shown to be ion channels themselves. While this last conclusion was initially questioned, it now seems to have been confirmed in several labs. Consequently these proteins may both regulate Piezo channels and be ion channels (Kang and Lee 2024). Only the best characteriized such channel is included here, so 1.A.154.1.1 and 8.A.113.1.1 are the same protein listed twice in TCDB.
References associated with 1.A.154 family:
Anderson, E.O., E.R. Schneider, J.D. Matson, E.O. Gracheva, and S.N. Bagriantsev. (2018). TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels. Cell Rep 23: 701-708. 29669276
Hong, G.S., B. Lee, J. Wee, H. Chun, H. Kim, J. Jung, J.Y. Cha, T.R. Riew, G.H. Kim, I.B. Kim, and U. Oh. (2016). Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neuron.s with Proprioceptive Function. Neuron. 91: 107-118. 27321926
Kang, H. and C.J. Lee. (2024). Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles. Exp Mol Med 56: 850-860. 38556553
Ojeda-Alonso, J., V. Bégay, J.A. Garcia-Contreras, A.F. Campos-Pérez, B. Purfürst, and G.R. Lewin. (2022). Lack of evidence for participation of TMEM150C in sensory mechanotransduction. J Gen Physiol 154:. 36256908
Pak, S., H. Ryu, S. Lim, T.L. Nguyen, S. Yang, S. Kang, Y.G. Yu, J. Woo, C. Kim, C. Fenollar-Ferrer, J.N. Wood, M.O. Lee, G.S. Hong, K. Han, T.S. Kim, and U. Oh. (2024). Tentonin 3 is a pore-forming subunit of a slow inactivation mechanosensitive channel. Cell Rep 43: 114334. 38850532